Seven repair technicians (RT, site A) repeatedly exposed to facsimile machine fume developed recurring sore throat, fever, lymphadenopathy, chest tightness, dry cough, and dyspnea.
The fume concentration was low (0.6 mg/m3 of breathing-zone air) but it contained butyl methacrylate (BMA), a known skin sensitizer.
Although chest radiographs were normal, three of the seven RT-A had lung crackles and spirometric abnormalities, and increased serum levels of immunoglobulins IgE or IgM.
Symptoms and most other abnormalities improved when exposure to BMA was stopped.
We later evaluated workers in two other sites (B and C).
Six RT-B had daily contact with BMA fume (0.14 to 0.40 mg/m3 of air) at a field repair depot.
Six administrative and six sales staff members (AS-B, SS-B) without regular fume exposure served as controls.
All RT-B had elevated serum IgE levels (202±69 U/mL [SEM] ; normal<41 U/mL).
IgE and fume levels were positively correlated (r=0.83).
Four RT-B had lung crackles, but few symptoms and normal results of spirometry.
The crackles cleared 8 weeks after substitution of a BMA-free paper, but IgE levels remained high (201±69).
The nonexposed AS-B and SS-B had no crackles.
Their IgE levels were normal (19±4 U/mL [SEM] ; p<0.01).
The crackles suggest BMA fume might have caused inflammation in terminal airways units.
The significance of the IgE elevations is also uncertain since this class of antibodies is usually associated with asthma, not pneumonitis. ...
Mots-clés Pascal : Intoxication, Fumée, Méthacrylate de butyle copolymère, Symptomatologie, Exploration clinique, Exploration microbiologique, IgM, IgE, Etude comparative, Homme, Toxicologie, Médecine travail, Appareil respiratoire pathologie, Poumon pathologie
Mots-clés Pascal anglais : Poisoning, Fumes, Butyl methacrylate copolymer, Symptomatology, Clinical investigation, Microbiological investigation, IgM, IgE, Comparative study, Human, Toxicology, Occupational medicine, Respiratory disease, Lung disease
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0227147
Code Inist : 002B03L02. Création : 199608.