logo BDSP

Base documentaire


Votre avis nous intéresse

Le réseau BDSP met en oeuvre un projet d'innovation et d'amélioration de ses services, dans le souci constant de proposer des contenus de qualité adaptés aux besoins des utilisateurs.

Identifier de nouvelles sources de financements est la condition nécessaire pour assurer la poursuite et la pérennité de cet outil unique qu'est la BDSP, tout en le faisant évoluer.

Pour définir un nouveau modèle économique, nous avons besoin de votre avis : merci de répondre à notre enquête (temps estimé : 5 minutes).

Participer maintenant
Participer plus tard J'ai déjà participé

  1. Hypersensitivity reactions and specific antibodies in workers exposed to industrial enzymes at a biotechnology plant.

    Article - En anglais

    Thirty-six employees who produced industrial enzymes from selected strains of bacteria and fungi were evaluated by epicutaneous threshold testing and enzyme-linked immunosorbent assays (ELISA) for specific IgE and IgG antibodies.

    The workers complained of'asthma-and flu-like'symptoms, which generally lessened away from work.

    The enzymes evaluated were :

    • alpha-amylase (1,4-alpha-d. glucan glucanohydrolase) from Bacillus licheniformis (alphaABl),

    • B. subtilis formation 1 (alphaAlBs) and B. subtilis formation 2 (alphaA2Bs) ;

    • purified alpha-amylase from B. licheniformis (CalphaABl) and A. oryzae (CalphaAAo) ;

    • alkaline protease from B. licheniformis (APBl) and purified alkaline protease (CAPBl) ;

    • amyloglucosidase (1,4-alpha-d-glucan glucohydrolase) from A. niger (AGAn) and purified amyloglucosidase (CAGAn).

    Statistically significant increases (P>0.05) in the proportion of workers having positive skin tests to CAPBl, AGAn and CAGAn were found.

    Significantly elevated (P>0.05) mean specific IgE results were observed for CalphaAAo CAGAn and AGAn, and elevated (P>0.05) mean specific IgGs were observed for CalphaAAo, CAGAn, AGAn, alphaAlBs, alphaABI and alphaA2Bs.

    These results indicate that occupational exposure to some industrial enzymes can cause immediate-onset cutaneous hypersensitivity reactions, pulmonary function deficits and significantly elevated specific antibody levels.

    Our results are equivocal as to whether work-related respiratory and cutaneous hypersen...

    Mots-clés Pascal : Enzyme, Fonction respiratoire, Génie génétique, Biotechnologie, Industrie, Exposition professionnelle, Médecine travail, Toxicité, Homme, Hypersensibilité, Technique ELISA, IgE, IgG, Allergie, Asthme, Immunopathologie, Appareil respiratoire pathologie, Test cutané

    Mots-clés Pascal anglais : Enzyme, Lung function, Genetic engineering, Biotechnology, Industry, Occupational exposure, Occupational medicine, Toxicity, Human, Hypersensitivity, ELISA assay, IgE, IgG, Allergy, Asthma, Immunopathology, Respiratory disease, Skin test

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0224239

    Code Inist : 002B03O. Création : 199608.