Alcohol and coronary heart disease : the evidence for a protective effect.
There is a considerable body of evidence indicating that moderate alcohol intake is associated with a reduced incidence of, and mortality from, coronary heart disease (CHD).
There is also substantial evidence that problem drinking (well beyond two drinks per day) is associated with increased cardiovascular mortality.
However, the frequently reported harmful effect of alcohol abuse on CHD mortality rates could be a result of mislabeling as CHD conditions such as alcohol-induced dilated cardiomyopathy, dysrhythmias, and hypertensive cardiovascular disease.
The combination of protective and harmful influences of alcohol consumption results in a U-shaped mortality curve.
A true protective effect of moderate intake of alcohol is likely, because of consistent findings in many large, well-conducted studies of diverse population samples and the apparent specificity of the protective effect for CHD and possibly atherosclerotic-thrombotic brain infarction.
There are also biologically plausible mechanisms whereby the protection might be conferred.
Alcohol has been shown convincingly to raise HDL subtractions which have been found to be protective against CHD, and it may also provide protection by an antithrombotic effect.
There is a suggestion that wine, and red wine in particular, may be more protective than other alcoholic beverages.
However, it is difficult to control adequately for confounding factors, since persons who prefer wine have been found to have a more ...
Mots-clés Pascal : Ethanol, Boisson alcoolisée, Consommation, Dose faible, Prévention, Homme, Relation dose réponse, Forme en U, Article synthèse, Cardiopathie coronaire, Appareil circulatoire pathologie
Mots-clés Pascal anglais : Ethanol, Alcoholic beverage, Consumption, Low dose, Prevention, Human, Dose activity relation, U shape, Review, Coronary heart disease, Cardiovascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0219698
Code Inist : 002B12A03. Création : 199608.