Decline in cognitive function in the elderly is common and represents a major clinical and public health concern.
Aspirin may reduce the decline in cognitive function by influencing multi-infarct dementia, but data are sparse.
The East Boston Senior Health Project is a population-based cohort study that enrolled 3,809 community-dwelling residents aged 65 years and older in 1982-1983 and followed them with home visits every 3 years until 1988-1989.
Trained interviewers assessed cognitive function by using the Short Portable Mental Status Questionnaire and assessed medication use, including over-the-counter drugs.
Response to the Short Portable Mental Status Questionnaire was scored as high, medium, or low, and decline was defined as transition to a lower category.
Participants who used drugs containing aspirin in the 2 weeks prior to the interview were classified as aspirin users.
Multiple logistic regression was used to obtain adjusted odds ratios and their 95% confidence intervals for decline of cognitive function.
The estimating equation approach was used to adjust the standard errors for repeated measurements.
Aspirin users had an odds ratio for cognitive decline of 0.97 (95% confidence interval 0.82-1.15).
Low frequency of aspirin use (less than daily) was associated with an odds ratio of 0.87 (95% confidence interval 0.69-1.09).
Although no substantial effect was observed, the data are also compatible with a modest benefit of aspirin, especially with ...
Mots-clés Pascal : Acétylsalicylique acide, Inhibiteur thromboagrégation, Prévention, Trouble cognition, Vieillard, Homme, Démence, Chimiothérapie, Epidémiologie, Massachusetts, Etats Unis, Amérique du Nord, Amérique, Salicylés, Maladie dégénérative, Système nerveux central pathologie, Système nerveux pathologie, Encéphale pathologie
Mots-clés Pascal anglais : Antiplatelet agent, Prevention, Cognitive disorder, Elderly, Human, Dementia, Chemotherapy, Epidemiology, Massachusetts, United States, North America, America, Salicylates, Degenerative disease, Central nervous system disease, Nervous system diseases, Cerebral disorder
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0218160
Code Inist : 002B02G. Création : 199608.