A total of 3,318 men and women from a region in rural China were randomized to receive daily either a multiple vitamin/mineral supplement or a placebo.
Deaths that occurred in the participants were ascertained and classified according to cause over the 6-year period from 1985 to 1991.
At the end of supplementation, blood pressure readings were taken, and the prevalence of hypertension was determined.
There was a slight reduction in overall mortality in the supplement group (relative risk (RR)=0.93,95% confidence interval (Cl) 0.75-1.16), with the decreased relative risk most pronounced for cerebrovascular disease deaths (RR=0.63,95% Cl 0.37-1.07).
This benefit was greater for men (RR=0.42,95% Cl 0.19-0.93) than for women (RR=0.93,95% Cl 0.44-1.98).
Among the survivors, the presence of elevations in both systolic and diastolic blood pressures was less common in those who received the supplement (RR for men=0.43,95% CI 0.28-0.65 ; RR for women=0.92,95% Cl 0.68-1.24).
This study indicates that supplementation with a multivitamin/mineral combination may have reduced mortality from cerebrovascular disease and the prevalence of hypertension in this rural population with a micronutrient-poor diet.
Mots-clés Pascal : Hypertension artérielle, Accident cérébrovasculaire, Epidémiologie, Supplémentation, Chimiothérapie, Vitamine, Elément minéral, Traitement, Antioxydant, Milieu rural, Chine, Asie, Homme, Mortalité, Appareil circulatoire pathologie, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, Cérébrovasculaire pathologie, Vaisseau sanguin pathologie
Mots-clés Pascal anglais : Hypertension, Stroke, Epidemiology, Supplementation, Chemotherapy, Vitamin, Inorganic element, Treatment, Antioxidant, Rural environment, China, Asia, Human, Mortality, Cardiovascular disease, Nervous system diseases, Central nervous system disease, Cerebral disorder, Cerebrovascular disease, Vascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0217047
Code Inist : 002B12B05B. Création : 199608.