To assess whether current thyroid status is associated with chondrocalcinosis or osteoarthritis (OA), we examined the cross sectional association of serum thyrotropin (thyroid stimulating hormone, TSH) with chondrocalcinosis and with knee OA in members of the Framingham OA study.
Knee radiographs were taken at the 18th biennial examination (1983-85) and measurement of serum TSH at either the 15th (1977-79) or the 18th biennial examination.
Chondrocalcinosis was dichotomized as absent or present and knee OA was based on a Kellgren and Lawrence score of grade 2 or greater in either knee.
Thyroid status was determined by serum TSH concentration classed into clinically relevant categories :
¾ 0.1 mU/l (low) ;
>0.1<0.4 mU/l (slightly low) ;
0.4 to 5.0 mU/l (normal) ;
>5 ¾ 10 mU/l (slightly high) ;
and>10 mU/l (high).
Data were collected on 577 men and 798 women.
We found no association between elevated serum TSH concentration and chondrocalcinosis.
Our results, though not statistically significant, suggest an inverse relation, with an odds ratio (OR) of 0.41 (95% CI 0.10,1.73) for those subjects in the highest TSH group and 1.79 (95% CI 0.39,8.24) for those in the lowest TSH group, compared to subjects in the normal range.
We found no association between serum TSH concentration and radiographic knee OA, with an OR of 0.85 (95% CI 0.47,1.51) for those in the highest serum TSH group and 1.51 (95% CI 0.54,4.22) for those in the lowest TS...
Mots-clés Pascal : Arthrose, Chondrocalcinose, Homme, TSH, Sérum, Exploration hormonale, Hypothyroïdie, Association, Epidémiologie, Etude transversale, Système ostéoarticulaire pathologie, Arthropathie, Chondropathie, Maladie dégénérative, Hormone adénohypophysaire, Hormone glycoprotéine, Endocrinopathie, Thyroïde pathologie, Etude Framingham
Mots-clés Pascal anglais : Osteoarthritis, Chondrocalcinosis, Human, TSH, Serum, Hormonal investigation, Hypothyroidism, Association, Epidemiology, Cross sectional study, Diseases of the osteoarticular system, Arthropathy, Chondropathy, Degenerative disease, Adenohypophyseal hormone, Glycoprotein hormone, Endocrinopathy, Thyroid diseases
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0216618
Code Inist : 002B15E. Création : 199608.