Developmental toxicity evaluation of sodium fluoride administered to rats and rabbits in drinking water.
Sodium fluoride (NaF ; Cas No. 7681-49-4) is used in fluoridating municipal water supplies, resulting in chronic exposure of millions of people worldwide.
Because of a lack of pertinent developmental toxicity studies in the literature, sodium fluoride was administered ad libitum in deionized/filtered drinking water (to mimic human exposure) to Sprague-Dawley-derived rats (26/group) on Gestation Days (GD) 6 through 15 at levels of 0,50,150, or 300 ppm and New Zealand White rabbits (26/group) on GD 6 through 19 at levels of 0,100,200, or 400 ppm.
Higher concentrations via drinking water were not practicable due to the poor palatability of sodium fluoride.
Drinking water (vehicle) contained less than 0.6 ppm sodium fluoride (limit of detection) and sodium fluoride content of the feed was 12.4 ppm fluoride (rats) and 15.6 ppm fluoride (rabbits).
Maternal food, water, body weights, and clinical signs were recorded at regular intervals throughout these studies.
Animals were killed on GD 20 (rats) or 30 (rabbits) and examined for implant status, fetal weight, sex, and morphological development.
In the high-dose group of both studies there was an initial decreased maternal body weight gain which recovered over time and a decreased water consumption-attributed to decreased palatability.
No clear clinical signs of toxicity were observed.
Maternal exposure to sodium fluoride during organogenesis did not significantly affect the frequency of postimplantation loss, mea...
Mots-clés Pascal : Sodium Fluorure, Additif alimentaire, Eau potable, Toxicité, Fluoration, Homme, Voie orale, Rat, Rodentia, Mammalia, Vertebrata, Animal, Lapin, Lagomorpha, Gestation pathologie, Tératogène, Malformation, Reproduction pathologie, Embryon, Foetus, Organogenèse
Mots-clés Pascal anglais : Sodium Fluorides, Food additive, Drinking water, Toxicity, Fluorination, Human, Oral administration, Rat, Rodentia, Mammalia, Vertebrata, Animal, Rabbit, Lagomorpha, Pregnancy disorders, Teratogen, Malformation, Reproduction diseases, Embryo, Fetus, Organogenesis
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0212448
Code Inist : 002B03H. Création : 199608.