Genetic counseling and predictive testing for colorectal cancer risk.
Workshop "Genetic Screening for Colorectal Cancer". , 1995/04/10.
In contrast to our rapidly increasing knowledge of the genetic basis of colorectal cancer and new molecular technologies, we are only in the early stages of characterizing the impact that this information will have on patients, their families and society.
From our research and clinical experience with hereditary colorectal cancer syndromes, we have developed a framework for risk assessment that includes criteria for identifying those at higher genetic risk and guidelines for genetic counseling, predictive genetic testing and follow-up management.
More research is needed to optimally translate this framework into wider clinical practice, including characterizing genetic heterogeneity and phenotype correlations, documenting the efficacy of screening and surgical interventions, and maximizing the awareness of health professionals on genetic counseling and the promise and limitations of gene tests.
Mots-clés Pascal : Tumeur maligne, Côlon, Rectum, Facteur risque, Génétique, Epidémiologie, Conseil génétique, Exploration, Valeur prédictive, Etats Unis, Amérique du Nord, Amérique, Héréditaire, Homme, Appareil digestif pathologie, Intestin pathologie, Côlon pathologie, Rectum pathologie, Maladie héréditaire, Lynch syndrome
Mots-clés Pascal anglais : Malignant tumor, Colon, Rectum, Risk factor, Genetics, Epidemiology, Genetic counseling, Exploration, Predictive value, United States, North America, America, Hereditary, Human, Digestive diseases, Intestinal disease, Colonic disease, Rectal disease, Genetic disease
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0211176
Code Inist : 002B13B01. Création : 199608.