Demographic determinants of hepatitis C virus seroprevalence among blood donors.
- To measure demographic determinants of hepatitis C virus (HCV) seroprevalence among blood donors in the United States.
- Cross-sectional epidemiological study.
- Five blood centers in different regions of the United States.
- A total of 862 398 consecutive volunteer blood donors with one or more nonautologous donations from March 1992 through December 1993.
- Demographic data collection, serological screening with second-generation anti-HCV enzyme immunoassay, and confirmation with anti-HCV recombinant immunoblot.
- There were 3126 donors with at least one blood donation confirmed HCV-seropositive, for a crude prevalence of 3.6 per 1000.
Age-specific HCV seroprevalence rose from 0.5 per 1000 in donors younger than 20 years to a maximum of 6.9 per 1000 in donors aged 30 to 39 years and declined in older age groups.
There was interaction between age and educational attainment, with 30-to 49-year-olds with less than a high school diploma at highest risk of HCV infection (odds ratio [OR], 33.0 ; 95% confidence interval [CI], 23.0 to 47.2 compared with those younger than 30 years with a bachelor's degree or higher degree).
Other independent risk factors for HCV seropositivity included male sex (OR, 1.9 ; 95% CI, 1.8 to 2.1), black race (OR, 1.7 ; 95% CI, 1.6 to 1.9), Hispanic ethnicity (OR, 1.3 ; 95% CI, 1.1 to 1.5), previous blood transfusion (OR, 2.8 ; 95% Cl, 2.5 to 3.1), and first/only time donor sta...
Mots-clés Pascal : Hépatite virale C, Virose, Infection, Donneur sang, Etats Unis, Amérique du Nord, Amérique, Epidémiologie, Homme, Appareil digestif pathologie, Foie pathologie
Mots-clés Pascal anglais : Viral hepatitis C, Viral disease, Infection, Blood donor, United States, North America, America, Epidemiology, Human, Digestive diseases, Hepatic disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0203818
Code Inist : 002B05C02G. Création : 199608.