At immunization contact, 165 infants 2.5 mo old were randomly assigned to receive either 15 mg vitamin A (retinyl palmitate) or placebo.
Three doses were given at monthly intervals with each diptheria, pertussis, tetanus and oral polio (DPT/OPV) immunization dose.
The diarrhea and acute respiratory infection (ARI) morbidity was similar in the vitamin A and placebo groups.
However, the duration (days per child-year, mean ± SD) of ARI was less in the vitamin A group compared with placebo group (27.6 ± 17.1 vs. 40.8 ± 22.7 ; P=0.005).
Fasting retinol concentrations were measured at entry and in 61 infants, the relative dose response (RDR) test was done 1 mo after the third dose of vitamin A. Eighty-five percent of the infants had serum retinol concentration<0.70 mol/L at entry.
After 3 mo the serum retinol levels improved significantly in both groups, and in the vitamin A-supplemented group the serum retinol concentration was significantly better than that in the placebo group (P=0.02).
However, 61% of the infants remained deficient despite vitamin A supplementation.
Among vitamin A-supplemented infants only, diarrhea and ARI morbidity during the 3-mo period were compared in children with normal versus children with abnormal RDR at the end of the supplementation period.
The ARI episodes were more frequent in the supplemented infants who remained vitamin A deficient at the end of the 3 mo (P=0.027).
Also, the cumulative duration (days, mean ± SD) of fever and ...
Mots-clés Pascal : Bengla Desh, Asie, Nourrisson, Homme, Prévention, Dose répétée, Voie orale, Efficacité traitement, Rétinol, Carence vitaminique, Etat nutritionnel, Morbidité, Infection, Voie respiratoire, Aigu, Diarrhée, Appareil respiratoire pathologie, ADP, Vitamine, Malnutrition, Pays en développement
Mots-clés Pascal anglais : Bangladesh, Asia, Infant, Human, Prevention, Multiple dose, Oral administration, Treatment efficiency, Retinol, Vitamin deficiency, Nutritional status, Morbidity, Infection, Respiratory tract, Acute, Diarrhea, Respiratory disease, ADP, Vitamin, Malnutrition, Developing countries
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0201505
Code Inist : 002B02N. Création : 199608.