Mantle-cell lymphoma : A population-based clinical study.
From a population-based non-Hodgkin's lymphoma (NHL) registry, 41 patients with mantle cell lymphoma (MCL) - a recently defined distinct B-cell NHL-were selected and compared with patients with low-or intermediate-grade NHL from the same registry.
Patients and Methods
The incidence and behavior of MCL in the area of the Comprehensive Cancer Center West (CCCW) from 1981 until 1989 were analyzed.
Age, performance, tumor bulk, extra nodal localization, stage, response to therapy, and survival were registered.
Expression of cyclin D1 protein and Ki-67 were measured in 29 patients.
MCL made up 3.7% of NHLs.
The median age was 68 years, and the male-to-female ratio was 1.6 : 1. Seventy-eight percent presented with stage IV, with the majority having bone marrow involvement.
The complete response (CR) rate was 32% (13 of 41), with a median duration of 25 months.
The median overall survival time was 31.5 months.
The International Prognostic Index identified five patients with a low-risk score and a median survival time of 93+months.
In 23 of 29 patients, cyclin D1 overexpression was present, without any relation to overall or disease-free survival.
In contrast, a proliferative index less than 10% was significantly related to a better overall survival time (50 v 24 months).
MCL is a disease of the elderly, who present with widespread disease and with a poor response to therapy.
Although it harbors features of an indolent NHL, it be...
Mots-clés Pascal : Lymphome non hodgkinien, Lymphocyte B, Homme, Pronostic, Survie, Incidence, Epidémiologie, Immunohistochimie, Phénotype, Hémopathie maligne, Lymphoprolifératif syndrome, Anatomopathologie, Lymphome lymphocytique intermédiaire, Lymphome centrocytique
Mots-clés Pascal anglais : Non Hodgkin lymphoma, B-Lymphocyte, Human, Prognosis, Survival, Incidence, Epidemiology, Immunohistochemistry, Phenotype, Malignant hemopathy, Lymphoproliferative syndrome, Pathology, Mantle cell lymphoma
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0200631
Code Inist : 002B19B. Création : 199608.