Objectives-To study individual effects on pulmonary function of exposure to hard metal including cobalt.
Methods-All of the workers in a hard metal company (583 men and 120 women) were examined for smoking, respiratory symptoms, ventilatory function, occupational history of exposure to hard metal, and present exposure to airborne cobalt.
The ventilatory function indices (forced vital capacity (FVC), forced expiratory volume in one second (FEV1), forced expiratory volume in one second per cent (FEV1%), peak expiratory flow (PEF), mid-maximal flow (MMF), forced expiratory flow at 50% vital capacity (V50), forced expiratory flow at 25% vital capacity (V25)) were standardised for height and age and expressed as a percentage of predicted values.
Two way analysis of variance of indices of ventilatory function showed that an interaction of hard metal exposure and smoking decreased% V50 for both men and women.
Among the currently exposed men, those with asthmatic symptoms (defined as reversible dispnoea with wheeze) had significantly lower% FVC,% FEV1%,% PEF,% MMF,% V50, and% V25 than did workers without asthma.
The ventilatory disfunction did not differ between exposed and non-exposed workers with asthmatic symptoms.
Even among the men without asthmatic symptoms,% V50 was significantly lowered by the interaction of hard metal exposure and smoking.
The multilinear regression analysis of indices of ventilatory function for all of the subjects on sex, smokin...
Mots-clés Pascal : Métal fritté, Cobalt, Industrie, Toxicité, Homme, Exposition professionnelle, Médecine travail, Fonction respiratoire, Ventilation, Expiration forcée, Capacité vitale forcée, Appareil respiratoire pathologie
Mots-clés Pascal anglais : Sintered metal, Cobalt, Industry, Toxicity, Human, Occupational exposure, Occupational medicine, Lung function, Ventilation, Forced expiration, Forced vital capacity, Respiratory disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0200578
Code Inist : 002B03L05. Création : 199608.