Investigation on neurotoxicity of occupational exposure to cyclohexane : a neurophysiological study.
Objectives-To examine the effect of occupational exposure to cyclohexane on the peripheral nervous system.
Methods-A nerve conduction study was performed on 18 workers exposed to cyclohexane in a luggage factory and on age and sex matched occupationally unexposed controls. 12 workers had been exposed to n-hexane (median 2.8 years) before the start of exposure to cyclohexane.
To confirm the effect of exposure, a follow up study was performed on nine workers one year after the first study.
The mean exposure to cyclohexane was 1.2 years in the first study.
A symptom survey was performed.
The exposure was measured by air sampling of the breathing zone of each worker.
The urinary metabolite cyclohexanol was also monitored.
The concentration of airborne cyclohexane ranged from 5 to 211 ppm.
The urinary concentration of cyclohexanol ranged from 0.12 to 1.51 mg/l. There was a strong correlation between the cyclohexane exposure in personal air and urinary cyclohexanol.
No differences were found in nerve conduction velocities (NCV) between workers exposed to cylohexane and age and sex matched controls.
The results of the follow up study showed significant improvements in peroneal motor NCV (P<0.01) and sural sensory NCV (P<0.05) and in ulnar motor distal latency (MDL, P<0.05) and peroneal MDL (P<0.05) compared with the first study.
Although the past n-hexane exposure affected the first neurophysiological study, the effect had disappeared in the second study,...
Mots-clés Pascal : Cyclohexane, Toxicité, Homme, Exposition professionnelle, Médecine travail, Système nerveux pathologie, Système nerveux périphérique, Epidémiologie, Japon, Asie, Test neuropsychologique, Solvant organique
Mots-clés Pascal anglais : Cyclohexane, Toxicity, Human, Occupational exposure, Occupational medicine, Nervous system diseases, Peripheral nervous system, Epidemiology, Japan, Asia, Neuropsychological test, Organic solvent
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0200574
Code Inist : 002B03L04. Création : 199608.