Objectives-To investigate the process of deciding on compensation claims by lung cancer patients exposed occupationally to coal tar pitch volatiles.
Methods-For each case of lung cancer the probability that it was caused (probability of causation (PC)) by coal tar pitch volatiles was expressed as an increasing function of cumulative exposure to benzo-a-pyrene-years.
This was assessed from several exposure-response models fitted to data from a large epidemiological study of aluminium production workers.
For some models, PC depended also on the smoking habit of the cancer patient.
Estimation of relative risk by exposure group indicated that over 50% of lung cancers were attributable to coal tar pitch volatiless (PC>50%) at exposures above 100 mug/m3-years benzo (a) pyrene.
A linear relative risk model indicated that 50% PC was first achieved at 342.2 mug/m3-years benzo (a) pyrene, or 190.1 mug/m3-years benzo (a) pyrene according to the upper 95% confidence limit for risk increment.
Corresponding figures for a power curve model were 210.3 and 45.9. With these five figures as compensation criteria compensation would have resulted in 31.4%, 2.7%, 19.2%, 15.7%, and 39.2% of cancers studied, compared with an estimated total proportion of cancers studied attributable to coal tar pitch volatiles of 15% - 26%. If risks due to coal tar pitch volatiles and smoking multiply, PC does not depend on the amount smoked.
If the two risks are additive, however, PC dep...
Mots-clés Pascal : Composé volatil, Brai houille, Toxicité, Exposition professionnelle, Médecine travail, Homme, Appareil digestif pathologie, Poumon, Tumeur maligne, Bronchopulmonaire, Benzo[a]pyrène, Epidémiologie, Canada, Amérique du Nord, Amérique, Indemnité dédommagement, Composé aromatique polycyclique, Relation dose réponse
Mots-clés Pascal anglais : Volatile compound, Coal tar pitch, Toxicity, Occupational exposure, Occupational medicine, Human, Digestive diseases, Lung, Malignant tumor, Bronchopulmonary, Epidemiology, Canada, North America, America, Indemnity, Polycyclic aromatic compound, Dose activity relation
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0198612
Code Inist : 002B11A. Création : 199608.