Objectives-Associations between occupational exposures and the occurrence of cutaneous melanoma were examined as part of a large population based case-control study of 19 cancer sites.
Methods-Cases were men aged 35 to 70 years old, resident in Montreal, Canada, with a new histologically confirmed cutaneous melanoma (n=103).
There were two control groups, a randomly selected population control group (n=533), and a cancer control group (n=533) randomly selected from among subjects with other types of cancer in the large study.
Odds ratios for the occurrence of melanoma were calculated for each exposure circumstance for which there were more than four exposed cases (85 substances, 13 occupations, and 20 industries) adjusting for age, ethnicity, and number of years of schooling.
Significantly increased risk of melanoma was found for exposure to four substances (fabric dust, plastic dust, trichloroethylene, and a group containing paints used on surfaces other than metal and varnishes used on surfaces other than wood), three occupations (warehouse clerks, salesmen, and miners and quarrymen), and two industries (clothing and non-metallic mineral products).
Conclusions-Most of the occupational circumstances examined were not associated with melanoma, nor is there any strong evidence from previous research that any of those are risk factors.
For the few occupational circumstances which were associated in our data with melanoma, the statistical evidence was...
Mots-clés Pascal : Etiologie, Epidémiologie, Canada, Amérique du Nord, Amérique, Mélanome, Homme, Exposition professionnelle, Médecine travail, Composé chimique, Peau pathologie, Tumeur, Etude cas témoin
Mots-clés Pascal anglais : Etiology, Epidemiology, Canada, North America, America, Melanoma, Human, Occupational exposure, Occupational medicine, Chemical compound, Skin disease, Tumor, Case control study
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0198604
Code Inist : 002B08A. Création : 199608.