Cancers in relatives of children with non-Hodgkin's lymphoma.
We undertook a family study of children treated at the Institute Gustave-Roussy in France to investigate a familial aggregation of cancer in the families of children with non-Hodgkin's lymphoma (NHL).
We obtained family data for 284 children with NHL.
Using the Standardized Incidence Ratio, we compared the observed and expected number of families with at least one proband relative affected by cancer at a young age (before 46 years).
We found a small but non-significant excess of all tumors in first-degree relatives (S/R=1.3,95% Cl=0.7-2.3) explained by a small but non-significant excess of hematological malignancies (SIR=1.5,95% Cl=0.2-5.5), particularly Hodgkin's disease and leukemia, and of osteosarcoma (SIR=7.5,95% Cl=0.1-41.4).
This is probably a lower bound of the SIR, because the expected number of families was estimated from cancer incidence in France between 1978 and 1982, whereas most cancers occurred before this period.
Other tumors were not in excess in first-degree relatives.
Mots-clés Pascal : Lymphome non hodgkinien, Prédisposition, Génétique, Hodgkin maladie, Leucémie, Tumeur maligne, Etude familiale, Epidémiologie, France, Europe, Enfant, Homme, Hémopathie maligne, Lymphoprolifératif syndrome, Lymphome
Mots-clés Pascal anglais : Non Hodgkin lymphoma, Predisposition, Genetics, Hodgkin disease, Leukemia, Malignant tumor, Family study, Epidemiology, France, Europe, Child, Human, Malignant hemopathy, Lymphoproliferative syndrome, Lymphoma
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0198087
Code Inist : 002B04B. Création : 199608.