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  1. Local cold exposure of the hands from cryosectioning work in histopathological and toxicological laboratories : signs and symptoms of peripheral neuropathy and Raynaud's phenomenon.

    Article - En anglais

    Objectives-To study relations between cryosectioning work, skin temperature, early signs of neuropathy in the hands, and vasospastic and neurological symptoms.

    Microtome work is carried out at histological and toxicological laboratories all over the world.

    It implicates local cold exposure of - 20°C on the hands of exposed laboratory technicians.

    Methods-Thirty nine laboratory technicians who use microtomes at the preclinical and clinical laboratories at the University of Uppsala, Sweden were studied.

    An equal number of non-exposed laboratory technicians served as controls, matched for workplace, sex, age, and smoking habits.

    Information on symptoms, type of work, and personal factors were assessed by means of a self administered questionnaire.

    Two point discrimination ability was tested, and vibration perception threshholds were measured for both hands by a bio-thesiometer.

    Also, skin temperature was measured during cryosectioning work in those 15 technicians performing cryosectioning work during the study period.


    Most laboratory technicians did not use any gloves during cryosectioning work, and direct contact with frozen materials sometimes occurred and resulted in a rapid cooling of the skin.

    In six of 15 exposed subjects (40%), the mean skin temperature during microtome work was below 20°C. A later rise in skin temperature, due to a compensatory vasodilation, was found in two subjects.

    The group exposed to cold had signs of early neuropathy on ...

    Mots-clés Pascal : Raynaud maladie, Neuropathie périphérique, Exposition professionnelle, Froid, Coupe à congélation, Personnel laboratoire, Histopathologie, Toxicologie, Homme, Toxicité, Main, Membre supérieur, Microtomie, Médecine travail, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Capillaire sanguin pathologie, Peau pathologie, Système nerveux autonome pathologie, Acrosyndrome, Système nerveux pathologie, Nerf périphérique pathologie

    Mots-clés Pascal anglais : Raynaud disease, Peripheral neuropathy, Occupational exposure, Cold, Cryosection, Laboratory staff, Histopathology, Toxicology, Human, Toxicity, Hand, Upper limb, Microtomy, Occupational medicine, Cardiovascular disease, Vascular disease, Capillary vessel disease, Skin disease, Diseases of the autonomic nervous system, Acrosyndrome, Nervous system diseases, Peripheral nerve disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0196392

    Code Inist : 002B12B03. Création : 199608.