To investigate the association between human T lymphotropic virus type I (HTLV-I) infection and rheumatoid arthritis (RA) in Nagasaki, an area highly endemic for HTLV-I infection.
Sera from 113 female patients with RA and 19,796 female blood donors were screened for anti-HTLV-I antibodies with a gelatin particle agglutination kit and confirmed using an immunoblotting kits.
The age-adjusted summary odds ratio of HTLV-I infection among RA patients, as compared with blood donors, was 2.8 (95% confidence interval [95% CI] 1.8-4.6).
The etiologic fraction, i.e., the proportion of RA in the study population that is attributable to HTLV-I infection, was estimated to be 13.2% (95% CI 5.1-21.2).
There was no significant difference in the clinical and laboratory findings between HTLV-I-infected and HTLV-I-uninfected RA patients.
These epidemiologic findings support the idea that HTLV-I infection is a risk factor for RA, and suggest that ~13% of the cases of RA in females living in Nagasaki are associated with HTLV-I infection.
Mots-clés Pascal : Polyarthrite rhumatoïde, Virus HTLV1, Retroviridae, Virus, Séropositivité, Prévalence, Anticorps, Facteur risque, Japon, Asie, Homme, Femelle, Epidémiologie, Chronique, Système ostéoarticulaire pathologie, Rhumatisme inflammatoire, Immunopathologie, Maladie autoimmune
Mots-clés Pascal anglais : Rheumatoid arthritis, HTLV-I virus, Retroviridae, Virus, Seropositivity, Prevalence, Antibody, Risk factor, Japan, Asia, Human, Female, Epidemiology, Chronic, Diseases of the osteoarticular system, Inflammatory joint disease, Immunopathology, Autoimmune disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0195186
Code Inist : 002B15D. Création : 199608.