Antibodies to prothrombin imply a risk of myocardial infarction in middle-age men.
Antiphospholipid antibodies in patients with « antiphospholipid syndrome » may be directed at least in part against plasma phospholipid-binding proteins, such as bêta2-glycoprotein I or prothrombin, which are involved in the control of thrombosis and haemostasis.
IgG-class antibodies against prothrombin and bêta2-glycoprotein I were measured by enzyme-linked immunoassay in initially healthy middle-aged dyslipidaemic men (non-high-density lipoprotein>5.2 mml/l).
Serum samples had been drawn at entry to a 5-year coronary primary-prevention trial with gemfibrozil from 106 subjects who experienced either a non-fatal myocardial infarction or cardiac death during the follow-up and from 106 subjects without coronary episodes, matched for treatment group (gemfibrozil/placebo) and geographical area.
The antiprothrombin antibody level, as expressed in optical density units, was significantly higher in patients than in controls (0.26 ± 0.17 versus 0.22 ± 0.09 ; p<0.02).
A high level of antiprothrombin antibodies (highest tertile of distribution) predicted a 2.5-fold increase in the risk (95% confidence interval 1.2-5.3) of myocardial infarction or cardiac death.
The distribution of IgG-class antibodies against bêta2-glycoprotein I did not differ significantly between cases and controls.
The joint effect of antiprothrombin antibodies and other factors associated with hypercoagulative state : triglyceride level, lipoprotein (a) and smoking, was multiplicative for the ris...
Mots-clés Pascal : Infarctus, Myocarde, Facteur risque, Anticorps, Prothrombine, Epidémiologie, Etude cohorte, Finlande, Europe, Age mûr, Adulte, Homme, Appareil circulatoire pathologie, Cardiopathie coronaire, Myocarde pathologie, Apolipoprotéine H
Mots-clés Pascal anglais : Infarct, Myocardium, Risk factor, Antibody, Prothrombin, Epidemiology, Cohort study, Finland, Europe, Middle age, Adult, Human, Cardiovascular disease, Coronary heart disease, Myocardial disease, Apolipoprotein H
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0195094
Code Inist : 002B12B03. Création : 199608.