High risk of Kaposi's sarcoma and central nervous system lymphoma in the same individuals : A finding related to acquired immunodeficiency syndrome.
Kaposi's sarcoma and central nervous system (CNS) lymphoma are the 2 most common malignancies related to HIV infection.
To investigate the association between Kaposi's sarcoma and CNS lymphoma, a population-based retrospective cohort study was conducted.
Using U.S. Surveillance, Epidemiology and End Results Program data, the gender-specific age-and calendar year-adjusted standardized incidence ratios were calculated for the pre-AIDS (1973-1980) and AIDS (1981-1990) eras, as an estimate of the relative risk (RR) of developing one condition following another.
For the AIDS era in men, the RR of CNS lymphoma following Kaposi's sarcoma was 979.7 and that of Kaposi's sarcoma following CNS lymphoma was 231.1 There were no instances of the co-occurrence of these malignancies in women in either era or in men for the pre-AIDS era.
The extremely high RRs for the co-occurrence of Kaposi's sarcoma and CNS lymphoma in men during the AIDS era suggests that the association of these malignancies occurs within the same HIV-infected individuals.
Mots-clés Pascal : Kaposi maladie, Adulte, Homme, Lymphome non hodgkinien, Système nerveux central, Second cancer, Epidémiologie, Association, Analyse risque, SIDA, Virose, Infection, Peau pathologie, Tumeur maligne, Hémopathie maligne, Lymphoprolifératif syndrome, Système nerveux pathologie, Immunopathologie, Immunodéficit
Mots-clés Pascal anglais : Kaposi sarcoma, Adult, Human, Non Hodgkin lymphoma, Central nervous system, Second cancer, Epidemiology, Association, Risk analysis, AIDS, Viral disease, Infection, Skin disease, Malignant tumor, Malignant hemopathy, Lymphoproliferative syndrome, Nervous system diseases, Immunopathology, Immune deficiency
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0193588
Code Inist : 002B04B. Création : 199608.