Alzheimer's disease : Preliminary study of spatial distribution at birth place.
International Symposium in Medical Geography. Vancouver, British Columbia CAN, 1994/07/12.
Alzheimer's disease (AD) is a neurodegenerative disorder which is characterized by a progressive loss of memory and the alteration of cognitive functions.
At least three chromosomal segments have been associated with early-onset AD in genetic linkage studies.
These results argue for a certain degree of heterogeneity in the genetic origin of some forms of AD, although environmental risk factors cannot be ruled out in late-onset AD.
In this preliminary study, we analyzed the geographical distribution of the birth places of a sample of 235 AD cases born in a defined region of Quebec (Canada), between 1895 and 1935.
We wished to test the hypothesis that risk factors acting at, or around birth place and time play a role in the etiology of AD.
The field of study was divided into rural and urban areas.
A reference population of live births was used to compute a measure of odds ratio (OR).
The OR results showed a statistically significant excess of AD cases in the rural area as compared to the reference population.
When stratified for sex, the OR results showed a global excess of female AD cases in both the rural and the urban areas.
For men, only the urban area presented a statistically significant deficit.
We also analyzed the structures of the genealogical kinships of the rural and urban sub-groups.
Although AD cases from the rural sub-group were more closely related to each other than those from the urban one, removal of the kin pairs from the OR analysis seem...
Mots-clés Pascal : Démence Alzheimer, Epidémiologie, Variation géographique, Homme, Sexe, Lieu naissance, Milieu rural, Milieu urbain, Facteur risque, Déterminisme génétique, Québec, Canada, Amérique du Nord, Amérique, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, Maladie dégénérative
Mots-clés Pascal anglais : Alzheimer disease, Epidemiology, Geographical variation, Human, Sex, Birth place, Rural environment, Urban environment, Risk factor, Genetic inheritance, Quebec, Canada, North America, America, Nervous system diseases, Central nervous system disease, Cerebral disorder, Degenerative disease
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Cote : 96-0190985
Code Inist : 002B17G. Création : 199608.