On rare occasions, exposure to methacrylates (MAs) may induce mucosal symptoms.
Three patients, two dental laboratory workers and one hearing aid laboratory worker, are presented.
All three had allergic contact dermatitis from MAs which disappeared after avoidance of contact with uncured MA compounds.
Two of the patients, the dental laboratory assistant and the hearing aid worker, had also developed symptoms of conjunctivitis.
Both were exposed to chemically curable and light-curable MAs.
The association between their conjunctivitis and type IV allergy to MAs was supported by the following observations : 1) sensitization to several MAs including methylMA, 2-hydroxyethylMA, ethyleneglycol diMA, triethyleneglycoldiMA, tetrahydrofurfuryldiMA, and 1,4-butanedioldiMA, as well as to pentaerythritol triacrylate ; 2) simultaneous appearance of their eye symptoms and allergic contact dermatitis ; 3) high exposure to MAs because of disturbances of ventilation ; 4) disappearance of the eye symptoms during holidays ; and 5) opthalmologist's findings of follicular conjunctivitis with some papillae, eosinophilia, and lymphocytosis in conjunctival scrapings corresponding to allergic contact conjunctivitis.
In addition, the activation of eosinophils in the conjunctival scrapings was demonstrated with the monoclonal antibody technique, and an elevated level of eosinophilic cationic protein was found in the tear fluid.
Our cases suggest that conjunctivitis may be caused by ...
Mots-clés Pascal : Conjonctivite, Allergie, Composé chimique, Toxicité, Dermatite contact, Hypersensibilité retardée, Méthacrylate polymère, Exposition professionnelle, Finlande, Europe, Homme, Oeil pathologie, Conjonctive pathologie, Maladie professionnelle, Médecine travail, Immunopathologie, Peau pathologie
Mots-clés Pascal anglais : Conjunctivitis, Allergy, Chemical compound, Toxicity, Contact dermatitis, Delayed hypersensitivity, Methacrylate polymer, Occupational exposure, Finland, Europe, Human, Eye disease, Conjunctiva disease, Occupational disease, Occupational medicine, Immunopathology, Skin disease
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0187379
Code Inist : 002B03L06. Création : 199608.