A multicentre prospective study was performed to estimate the incidence of hospital infections and to identify the most relevant risk factors for sepsis in a large and unselected population of high-risk newborns.
The study involved 49 neonatal intensive care units and 17 neonatal intermediate care units in Italy.
Newborns were followed up from admittance to the units until discharge.
Data on demographics and clinical characteristics, exposure to the principal invasive procedures, and onset of infectious complications were prospectively collected.
Only infections developing after 48 h from admittance to the unit were recorded.
A multiple logistic regression was performed to identify which factors were independently associated with sepsis.
Among the 8263 newborns included in the analysis, the incidence of infected newborns was 14.4 per 100 newborns and 0.9/100 days of stay.
The incidence of infections was 19.1/100 newborns and 1.2/100 days of stay.
Sepsis represented 15.4% of all infections (incidence 2.9/100 newborns and 0.2/100 days of stay).
The following factors were independently associated with sepsis :
umbilical catheterization, both through the vein and the artery for more than 5 days ;
mechanical ventilation for more than 5 days ;
necrotizing enterocolitis ;
birth weight equal to or less than 2500 g ;
nasogastric tube ;
total parenteral nutrition ;
and transfer from other hospitals.
Umbilical catheters accounted for the highest proportion of sepsis ...
Mots-clés Pascal : Infection nosocomiale, Nouveau né, Homme, Facteur risque, Epidémiologie, Etude multicentrique, Unité soin intensif, Incidence, Italie, Europe
Mots-clés Pascal anglais : Nosocomial infection, Newborn, Human, Risk factor, Epidemiology, Multicenter study, Intensive care unit, Incidence, Italy, Europe
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0182299
Code Inist : 002B27B11. Création : 199608.