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  1. Fulltext. A prospective cohort study on the relationship between onion and leek consumption, garlic supplement use and the risk of colorectal carcinoma in The Netherlands.

    Article - En anglais


    The association between onion and leek consumption, garlic supplement use and colon and rectum carcinoma among men and women was evaluated in the Netherlands Cohort Study, a large-scale prospective cohort study on diet and cancer.

    Onions, leeks, and garlic belong to the Allium genus and contain large amounts of potentially chemopreventive compounds.

    The Netherlands Cohort Study was started in 1986 among 120 852 men and women, aged 55-69 years.

    Dietary intake was measured with a 150-item food frequency questionnaire.

    After 3.3 years of follow-up, 150 and 143 incident male and female cases of colon carcinoma, and 93 and 57 cases of rectum carcinoma, respectively, with complete dietary data were available for analysis.

    Dietary data were available for 1525 men and 1598 women of a randomly selected subcohort, that was followed up to estimate person-time in the entire cohort.

    In men, the adjusted rate ratios (RRs) in multivariable analysis for colon and rectum carcinoma in the highest compared to the lowest onion consumption categories were 0.87 (95% confidence interval [CI]=0.48-1.65), and 0.66 (95% CI=0.28-1.52), respectively.

    The RRs for proximal colon carcinoma were lower than for distal colon carcinoma.

    Leek consumption was not associated with colon and rectum carcinoma incidence in men.

    None of the RRs were significantly different from unity and no trends in the RRs were detected.

    A lower risk was found for rectum carcinoma in women consuming less than 0.2...

    Mots-clés Pascal : Oignon, Poireau, Ail, Régime alimentaire enrichi, Supplémentation, Aliment, Origine végétale, Allium, Liliaceae, Monocotyledones, Angiospermae, Spermatophyta, Carcinome, Côlon, Rectum, Facteur risque, Toxicité, Etude cohorte, Alimentation, Homme, Epidémiologie, Tumeur maligne, Appareil digestif pathologie, Intestin pathologie, Côlon pathologie, Rectum pathologie, Pays Bas, Europe

    Mots-clés Pascal anglais : Onion, Leek, Garlic, Supplemented diet, Supplementation, Food, Plant origin, Allium, Liliaceae, Monocotyledones, Angiospermae, Spermatophyta, Carcinoma, Colon, Rectum, Risk factor, Toxicity, Cohort study, Feeding, Human, Epidemiology, Malignant tumor, Digestive diseases, Intestinal disease, Colonic disease, Rectal disease, Netherlands, Europe

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0182099

    Code Inist : 002B04E05. Création : 199608.