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  1. A reduced dose approach to hepatitis B vaccination for low-risk newborns and preschool children.

    Article - En anglais

    The effectiveness ofa 2.5 ƒg dose of the hepatitis B vaccine (B-Hepavac II) was compared with that of 5 ƒg in 587 low-risk neonates and 777 preschool children of age 3-8 years.

    The vaccines were administered at months 0,1 and 3, with postvaccination serology tested at months 4 and 12.

    The seroconversion rates of the 2.5 ƒg recipients (newborn : 93.5% ; preschool children : 97.4%) are comparable with the 5 ƒg group (newborn : 95.7% ; preschool children : 98.7%). The seroconversion rates of the newborns are, however, significantly lower in the 2.5 ƒg group if positive response is taken as a titre>10 IU l#F-#F1, instead of>0 IU l#F-#F1.

    The older children, on the other hand, achieved a higher seroconversion rate and geometric mean titre (GMT) when compared with the newborns, irrespective of the dose received.

    Mots-clés Pascal : Virus hépatite B, Hepadnaviridae, Virus, Vaccin, Dose faible, Nouveau né, Homme, Age préscolaire, Séropositivité, Immunoprotection, Sérologie, Santé publique, Vaccination

    Mots-clés Pascal anglais : Hepatitis B virus, Hepadnaviridae, Virus, Vaccine, Low dose, Newborn, Human, Preschool age, Seropositivity, Immunoprotection, Serology, Vaccination

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0173438

    Code Inist : 002B05C02G. Création : 199608.