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  1. Cigarette smoking and bone mineral density in the elderly.

    Article - En anglais

    Objective

    To test the hypothesis that cigarette smoking is associated with reduced bone mineral density in elderly men and women.

    Design

    Cross sectional study.

    Subjects

    These comprised 224 men and 186 women aged 61-73 years, born and resident in East Hertfordshire.

    Measurements

    Lumbar spine and femoral neck bone mineral density (BMD) were determined by dual energy x ray absorptiometry.

    Results

    After adjusting for potential confounding variables, men who were current smokers were found to have a lumbar spine BMD that was 7.3% (95% CI 0.4,14.2) lower than men who had never smoked.

    Similarly, women who were current smokers had a BMD value that was 7.7% (95% CI 0.3,15.6) lower than in women who had never smoked.

    The difference at the femoral neck was smaller and not statistically significant.

    For both men and women, each decade of smoking was associated with a reduction of 0.015 g/cm#F2 in BMD at the lumbar spine (95% CI : men 0.002,0.027 ; women 0.003,0.028).

    At the femoral neck the reduction in BMD was 0.011 g/cm#F2 (95% CI 0.003,0.020) for men and 0.004 g/cm#F2 (95% CI - 0.003,0.012) for women with each decade of smoking.

    Conclusions

    The results show an adverse effect of smoking on BMD which was most noticeable at the lumbar spine, and seemed stronger in men than women.

    This effect could not be explained by differences in life style between smokers and non-smokers.

    Mots-clés Pascal : Tabagisme, Toxicité, Epidémiologie, Densité, Os, Vieillard, Homme, Sexe, Rachis lombaire, Col fémoral, Système ostéoarticulaire, Santé publique, Angleterre, Grande Bretagne, Royaume Uni, Europe

    Mots-clés Pascal anglais : Tobacco smoking, Toxicity, Epidemiology, Density, Bone, Elderly, Human, Sex, Lumbar spine, Femoral neck, Osteoarticular system, England, Great Britain, United Kingdom, Europe

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0167092

    Code Inist : 002B03E. Création : 199608.