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  1. An epidemiological study after a water contamination incident near Worcester, England in April 1994.

    Article - En anglais

    Study objectives

    To investigate whether exposure to tap water contaminated in a major river pollution incident with 2 ethyl 5,5 dimethyl 1,3 dioxane (EDD) and 2 ethyl 4 methyl 1,3 dioxolane (EMD) was associated with an increase of self reported symptoms.

    To assess the extent of association between noticing the water had an unusual taste or odour and self reported symptoms.


    Retrospective cohort study.


    A city and two nearby towns in a semi-rural area of England, UK.


    A total of 3861 people who replied to a postal questionnaire asking about symptoms and water consumption sent to a sample of 1000 households in each of three areas - one area supplied with contaminated water (study group) and two control areas that were unaffected (control groups).

    Main results

    The household response rates were 65% for the study group and 56% and 57% for the two control groups.

    Self reporting of 10 individual symptoms was significantly increased in the study group compared with controls.

    Within the study group, reporting of one or more symptoms was significantly higher in subjects who consumed contaminated water but not among subjects who used it to wash or cook.

    Subjects who drank contaminated water showed a dose-response relationship for self reporting of one or more symptoms and for seven individual symptoms.

    Within the study group, however, only 62% (867 of 1398 subjects) noticed that the water had an unusual taste or odour.

    Among subject...

    Mots-clés Pascal : Dioxane dérivé, Solvant organique, Dioxolane dérivé, Contamination, Eau potable, Céphalée, Nausée, Epidémiologie, Accident, Homme, Détection, Odeur, Toxicité, Santé publique, Douleur, Système nerveux pathologie, Trouble neurologique, Angleterre, Grande Bretagne, Royaume Uni, Europe, 1,3-dioxane(5,5-diméthyl 2-éthyl), 1,3-dioxolane(2-éthyl 4-méthyl)

    Mots-clés Pascal anglais : Dioxane derivatives, Organic solvent, Dioxolane derivatives, Contamination, Drinking water, Headache, Nausea, Epidemiology, Accident, Human, Detection, Odor, Toxicity, Pain, Nervous system diseases, Neurological disorder, England, Great Britain, United Kingdom, Europe

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0167087

    Code Inist : 002B03H. Création : 199608.