Objectives The objective of the study was to examine cancer incidence and identify risk factors among subjects born in 1925-1971 and engaged in agricultural activities in Norway.
Methods A cohort was established through linkage between agricultural censuses in 1969-1989 and the Central Population Register, which identifies farm holders and their spouses.
Available census information on the activity of the farm provided the exposure indicators.
Incident cancer in 1969-1991 was identified in the Cancer Register.
In an analysis for standardized incidence ratios (SIR), the cohort was compared with the total rural population of Norway.
Associations with exposure indicators were investigated in a Poisson regression analysis.
Results In the follow-up of 136 463 men for 1.5 million person-years and 109 641 women for 0.6 million person-years, 3333 and 2145 cancer cases were identified, respectively.
The subset defined as farmers had an SIR of 77 epsilon95% confidence interval (95% CI) 73-81zêta for the men and 92 (95% CI 85-99) for the women, with particularly low SIR values for lung cancer and other sites linked to life-style.
The several positive associations found confirmed the a priori hypothesis of an association between dairy farming and acute leukemia among men epsilonrate ratio 1.76,95% CI 1.02-3.05zêta.
Multiple myeloma was associated with pesticide indicators for both genders, mainly for subjects cultivating potatoes.
Conclusions The results support the h...
Mots-clés Pascal : Tumeur maligne, Exposition professionnelle, Agriculture, Homme, Sexe, Epidémiologie, Incidence, Facteur risque, Etude cohorte, Elevage, Pesticide, Norvège, Europe, Santé publique, Médecine travail
Mots-clés Pascal anglais : Malignant tumor, Occupational exposure, Agriculture, Human, Sex, Epidemiology, Incidence, Risk factor, Cohort study, Rearing, Pesticides, Norway, Europe, Occupational medicine
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0164961
Code Inist : 002B04B. Création : 199608.