Regional differences in albuminuria among American Indians : An epidemic of renal disease.
Albuminuria is a risk factor for renal and cardiovascular disease.
We conducted a cross sectional survey of 4549 older American Indians in Arizona, Oklahoma and North and South Dakota of (micro) albuminuria.
A range of 20.1 to 48.3% of all participants had either micro- (kappa 30 to<300 mg albumin/g creatinine) or macroalbuminuria (kappa 300 mg albumin/g creatinine).
A total of 53% of the participants were diabetic, and the prevalence in Arizona (65 to 70%) was significantly greater than the other two sites.
Prevalence of micro-and macroalbuminuria were significantly higher among those who were older, diabetic or hypertensive, and participants from Arizona.
Even normotensive, nondiabetic Arizona Indians had higher prevalence rates than similar participants elsewhere.
Higher prevalence rates of micro-and macroalbuminuria were also found among Arizona participants than participants with similar degrees of glucose intolerance from the other two sites.
Indians reporting the greatest degree of Indian blood were more likely to have abnormal albuminuria (P<0.0001).
The duration of diabetes, fasting plasma glucose, systolic blood pressure, fibrinogen and Indian heritage were independently associated with micro-or macroalbuminuria.
The association of albuminuria with subsequent ESRD, cardiovascular morbidity and overall mortality suggests that these American Indians will face a large disease burden.
The correlation with reported Indian blood implies a strong compon...
Mots-clés Pascal : Protéinurie, Microalbuminurie, Prévalence, Epidémiologie, Association, Obésité, Diabète, Hypertension artérielle, Adulte, Homme, Vieillard, Amérindien, Etats Unis, Amérique du Nord, Amérique, Etude multicentrique, Etat nutritionnel, Appareil urinaire pathologie, Trouble nutrition, Endocrinopathie, Appareil circulatoire pathologie, Santé publique
Mots-clés Pascal anglais : Proteinuria, Microalbuminuria, Prevalence, Epidemiology, Association, Obesity, Diabetes mellitus, Hypertension, Adult, Human, Elderly, Amerindian, United States, North America, America, Multicenter study, Nutritional status, Urinary system disease, Nutrition disorder, Endocrinopathy, Cardiovascular disease
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0164822
Code Inist : 002B14E01. Création : 199608.