Although there is a consensus that orofacial and limbtruncal subtypes of tardive dyskinesia (TD) exist and may represent distinct pathophysiologic entities, few studies have examined the incidence of and risk factors associated with the development of these TD subtypes.
Two hundred and sixty-six middle-aged and elderly outpatients with a median duration of 21 days of total lifetime neuroleptic exposure at study entry were evaluated at 1-to 3-month intervals.
Using « mild » dyskinesia in any part of the body for diagnosis of TD, the cumulative incidence of orofacial TD was 38.5 and 65.7% after 1 and 2 years, respectively, whereas that of limbtruncal TD was 18.6 and 32.6% after 1 and 2 years.
Preclinical dyskinesia was predictive of both orofacial and limbtruncal TD.
History of alcohol abuse or dependence was a significant predictor of orofacial TD only whereas tremor was a significant predictor of limbtruncal TD only.
Findings support suggestions that orofacial and limbtruncal TD may represent specific subsyndromes with different risk factors.
Mots-clés Pascal : Vieillard, Homme, Psychotrope, Neuroleptique, Dyskinésie, Dyskinésie buccofaciale, Toxicité, Traitement, Chimiothérapie, Long terme, Facteur risque, Epidémiologie, Santé publique, Système nerveux pathologie, Trouble neurologique, Mouvement involontaire, Extrapyramidal syndrome
Mots-clés Pascal anglais : Elderly, Human, Psychotropic, Neuroleptic, Dyskinesia, Buccofacial dyskinesia, Toxicity, Treatment, Chemotherapy, Long term, Risk factor, Epidemiology, Nervous system diseases, Neurological disorder, Involuntary movement, Extrapyramidal syndrome
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0164795
Code Inist : 002B02U01. Création : 199608.