Risk of nervous system cancer among workers exposed to lead.
Experimental animal studies suggest that lead compounds may increase the risk of gliomas.
To study whether occupational exposure to lead increase the risk, we followed nervous system cancer incidence among 20,741 employees biologically monitored for their blood lead (B-Pb) concentrations.
We also performed a nested case-referent study, comprising 26 male cases of nervous system cancer (16 of which had gliomas).
Those cases a B-Pb kappa 1.4 mol/L had a twofold increase in the odds ratio of nervous system cancer as compared with those employees whose B-Pb had not exceeded 0.7 mol/L. The excess was confined to gliomas (odds ratio 11,95% confidence interval 1.0 to 630 for B-Pb kappa 1.4 mol/L ; overall P value for trend, 0.037).
We obtained lifetime information on exposure and potential confounders for 58% of the cases.
The odds ratio of glioma was associated with indices of lifetime exposure to lead, and potential confounders seemed not to explain the effects.
The results suggest that there may be an association between occupational lead exposure and the risk of gliomas.
No firm conclusions can be drawn because of the small number of cases and loss of material.
Mots-clés Pascal : Gliome, Exposition professionnelle, Plomb, Métal lourd, Homme, Epidémiologie, Médecine travail, Santé publique, Toxicité, Système nerveux pathologie, Système nerveux central pathologie, Tumeur
Mots-clés Pascal anglais : Glioma, Occupational exposure, Lead, Heavy metal, Human, Epidemiology, Occupational medicine, Toxicity, Nervous system diseases, Central nervous system disease, Tumor
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0163530
Code Inist : 002B17E. Création : 199608.