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  1. High prevalence of arthropathy in HTLV-I carriers on a Japanese island.

    Article - En anglais

    Objective

    To determine the aetiological relationship between human T cell leukaemia virus type-I (HTLV-I) and arthritis, by performing an epidemiological study of the inhabitants of Tsushima, an island northwest of the main island of Kyushu, Japan, which is an endemic area of HTLV-I.

    Methods-A total of 7087 people underwent an annual health check, and those with arthropathy had further physical and radiological examinations by rheumatologists.

    The presence of HTLV-I antibody was determined by the particle agglutinin method, and integration of the proviral DNA in peripheral lymphocytes was confirmed by polymerase chain reaction.

    Results

    HTLV-I was positive in 26.1% of inhabitants ; the incidence increased to 37.0% in patients with symptoms of polyarthritis.

    The prevalence of rheumatoid arthritis (RA) was significantly different between HTLV-I carriers (0.56%) and non-carriers (0.31%). The stage of bone destruction in HTLV-I carriers with articular symptoms was milder than that in RA patients without HTLV-I.

    The relative risk of HTLV-I infection for polyarthritis was 1.66 (p<0.05).

    Conclusion-This is the first epidemiological report clarifying the association between HTLV-I and polyarthritis.

    Our results suggest that this viral infection has a relationship to RA.

    Mots-clés Pascal : Leucémie, Virus HTLV1, Retroviridae, Virus, Etiologie, Polyarthrite, Epidémiologie, Virose, Infection, Japon, Asie, Homme, Hémopathie maligne, Système ostéoarticulaire pathologie, Arthropathie, Santé publique

    Mots-clés Pascal anglais : Leukemia, HTLV-I virus, Retroviridae, Virus, Etiology, Polyarthritis, Epidemiology, Viral disease, Infection, Japan, Asia, Human, Malignant hemopathy, Diseases of the osteoarticular system, Arthropathy

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0162328

    Code Inist : 002B05C02C. Création : 199608.