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  1. Cholesterol screening in asymptomatic adults, revisited.

    Article - En anglais


    To assess the role of serum lipid levels as screening tests in adults.


    Pooled analysis of clinical trials, supplemented by analysis of data from the Framingham Heart Study, to estimate the effect of cholesterol reduction in patient groups stratified by cardiac risk.

    Study Selection 

    Published randomized controlled trials of cholesterol reduction, meta-analyses of such trials, prospective cohort studies of the association between cholesterol levels and morbidity and death related to coronary heart disease, and cost-effectiveness analyses of cholesterol reduction.

    Data Analysis 

    Two-stage logistic regression on cardiac risk factors and outcomes in the Framingham Heart Study.

    The first stage predicted the risk for death from coronary heart disease using standard risk factors but not cholesterol ; the second stage predicted the risk for death from coronary heart disease and all causes as functions of age and cholesterol level, stratified by the risk predicted from the first stage.


    Randomized clinical trials show that cholesterol reduction confers survival benefits in patients with symptomatic coronary disease.

    In asymptomatic middle-aged men, who are at lower risk for death from coronary disease, cholesterol reduction prevents coronary disease but has not been shown to prolong life.

    The risk model based on analysis of the data from the Framingham Heart Study is consistent with the randomized trial data and shows that in the dem...

    Mots-clés Pascal : Concentration, Cholestérol, Sérum, Analyse, Intérêt, Prévention, Population, Facteur risque, Attitude, Epidémiologie, Homme

    Mots-clés Pascal anglais : Concentration, Cholesterol, Serum, Analysis, Interest, Prevention, Population, Risk factor, Attitude, Epidemiology, Human

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0162088

    Code Inist : 002B30A01A2. Création : 199608.