We investigated the hypothesis that prenatal exposure to the 1957 A2 influenza increases the risk of schizophrenia in adulthood.
We traced a cohort of individuals known to have been exposed to the 1957 influenza epidemic during gestation and an unexposed cohort matched for period of gestation and hospital of birth.
Follow-up information on psychiatric illness in subjects was sought from two sources : maternal interview and psychiatric hospital admission data.
Follow-up information was obtained on 54% of the sample : 238 subjects from the influenza-exposed group and 287 subjects from the unexposed group.
There was no increased risk of schizophrenia among the exposed cohort compared to the unexposed cohort (relative risk 1.1 ; 95% Cl 0.41-2.95), although there was an increase in depressive illness (relative risk 1.59 ; 95% Cl 1.15-2.19).
The association between prenatal influenza and an increased risk of schizophrenia in adulthood has thus far been found only in population-based data and is not supported by the present observational study which has information about exposure and outcome in individuals.
Mots-clés Pascal : Schizophrénie, Psychose, Etiologie, Exposition, Prénatal, Influenzavirus A, Influenzavirus, Orthomyxoviridae, Virus, Etude longitudinale, Facteur risque, Adulte, Homme, Epidémiologie, Santé publique
Mots-clés Pascal anglais : Schizophrenia, Psychosis, Etiology, Exposure, Prenatal, Influenzavirus A, Influenzavirus, Orthomyxoviridae, Virus, Follow up study, Risk factor, Adult, Human, Epidemiology
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0161528
Code Inist : 002B18C06A. Création : 199608.