In developing countries, both marginal vitamin A status and intestinal helminths are common among children.
Indonesian children (n=309,0.6-6.6 y), known to be infected with Ascaris lumbricoides, were randomized into six different treatment groups (A-F).
The treatments included 210 mol vitamin A supplement and a dose of 400 mg albendazole (5-propylthio-1H-benzimidazol-2-yl carbamic acid methyl ester) administered orally either at the same health visit (Groups B and F) or at different contact times during a 1-mo period (groups A, C, D and E).
Vitamin A status was assessed both before and 3-4 wk after the treatments by the modified relative dose response (MRDR) test.
Vitamin A supplementation was most important in improving the vitamin A status (P<0.0001) of these children, whereas treatment for ascariasis alone (P=0.370) and the statistical interaction between treatment for ascariasis and vitamin A (P=0.752) were not.
Serum retinol concentrations marginally improved (P=0.051) in two of the groups that received vitamin A and albendazole but not in the third group that received vitamin A only.
The MRDR test proved a better discriminator of the effects of these treatments on vitamin A status than changes in serum retinol concentrations.
Mots-clés Pascal : Java, Indonésie, Asie, Enfant, Homme, Chimiothérapie, Traitement, Association médicamenteuse, Interaction médicamenteuse, Albendazole, Rétinol, Etat nutritionnel, Ascaridiase, Nématodose, Helminthiase, Parasitose, Infection, Ascaris lumbricoides, Nematoda, Nemathelminthia, Helmintha, Invertebrata, Pays en développement, Santé publique, Politique sanitaire, Benzimidazole dérivé, Anthelminthique, Antiparasitaire, Vitamine
Mots-clés Pascal anglais : Java, Indonesia, Asia, Child, Human, Chemotherapy, Treatment, Drug combination, Drug interaction, Retinol, Nutritional status, Ascariasis, Nematode disease, Helminthiasis, Parasitosis, Infection, Ascaris lumbricoides, Nematoda, Nemathelminthia, Helmintha, Invertebrata, Developing countries, Health policy, Benzimidazole derivatives, Anthelmintic, Parasiticid, Vitamin
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0154293
Code Inist : 002B02N. Création : 199608.