Persistent diarrhea (PD) and dysentery (DD) account for most diarrhea-associated deaths among children in developing countries.
Zinc deficiency can cause stunting and impaired immune function, both of which are risk factors for these diarrheal illnesses.
We investigated the effect of zinc supplementation on the incidence of PD and DD in a community-based, double-blind randomized trial in children 6-35 mo of age.
Increase over baseline in plasma zinc concentrations in the supplemented group compared with a control group (3.61 vs. 0.009 mol.
L#F-#F1) indicated successful supplementation.
The overall reductions in the zinc supplemented group of 21% in the incidence of PD (95% Cl - 6 to 42%) and 14% in the incidence of dysentery (95% Cl - 15 to 36%) were not significant.
There was a significant interaction of treatment effect with baseline plasma zinc concentration and age for PD and with gender for DD.
In the zinc-supplemented group compared with the control group, the incidence of PD was reduced by 73% (P<0.05 ; 95% Cl 34 to 91%) in children with a baseline zinc<7.65 mol.
L#F-#F1 and by 49% (P<0.05 ; 95% Cl 24 to 66%) in children>11 mo of age.
Zinc supplementation resulted in a 38% (P<0.05 95% Cl 8 to 59%) reduction in the incidence of DD in boys.
There was no effect on PD among children 6-11 mo old or on DD in girls.
In conclusion, zinc supplementation had a significant impact on the incidence of persistent diarrhea in children>1 y old and in children wit...
Mots-clés Pascal : Inde, Asie, Statut socioéconomique, Faible, Enfant, Homme, Incidence, Zinc, Chimiothérapie, Régime alimentaire enrichi, Diarrhée, Chronique, Bactériose, Infection, Dysenterie, Santé publique, Pays en développement, Appareil digestif pathologie, Intestin pathologie, Elément minéral, Oligoélément, Etat nutritionnel
Mots-clés Pascal anglais : India, Asia, Socioeconomic status, Low, Child, Human, Incidence, Zinc, Chemotherapy, Supplemented diet, Diarrhea, Chronic, Bacteriosis, Infection, Dysentery, Developing countries, Digestive diseases, Intestinal disease, Inorganic element, Trace element (nutrient), Nutritional status
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0154292
Code Inist : 002B02N. Création : 199608.