Vitamin A supplementation of populations of vitamin A-deficient preschool-age children has been shown to reduce childhood mortality, but the primary preventive effects of such supplements on childhood infectious diseases have not been carefully evaluated.
We conducted an individually randomized, placebo-controlled, double-masked trial among 1,407 Indonesian preschool-age children, to measure the effects of high dose vitamin A on acute respiratory and diarrheal illnesses.
Signs and symptoms of morbidity were monitored using every other day home surveillance by trained Interviewers.
High dose vitamin A supplements Increased the incidence of acute respiratory illnesses (ARI) by 8%, and acute lower respiratory illnesses (ALRI) by 39%. These detrimental effects on acute lower respiratory illnesses were most marked in children with adequate nutritional status (rate ratio 1.83,95% confidence interval 1.257-2.669).
In contrast, vitamin A tended to be protective of ALRI in chronically malnourished children (rate ratio 0.71,95% confidence interval 0.375-1.331).
There was no overall effect of high-dose vitamin A supplements on the incidence of diarrheal disease (rate ratio 1.06,95% confidence interval 0.920-1.225).
However, we found a significant interaction between supplementation and age : vitamin A increased the incidence of diarrhea in children<30 mo of age, but tended to reduce the incidence in older children.
The finding of a significant adverse effect of vitam...
Mots-clés Pascal : Java, Indonésie, Asie, Milieu rural, Age préscolaire, Enfant, Homme, Chimiothérapie, Régime alimentaire enrichi, Rétinol, Carence vitaminique, Prévalence, Incidence, Diarrhée, Appareil respiratoire pathologie, Aigu, Morbidité, Pays en développement, Vitamine, Intestin pathologie, Appareil digestif pathologie, Santé publique, Politique sanitaire, Malnutrition, Etat nutritionnel
Mots-clés Pascal anglais : Java, Indonesia, Asia, Rural environment, Preschool age, Child, Human, Chemotherapy, Supplemented diet, Retinol, Vitamin deficiency, Prevalence, Incidence, Diarrhea, Respiratory disease, Acute, Morbidity, Developing countries, Vitamin, Intestinal disease, Digestive diseases, Health policy, Malnutrition, Nutritional status
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0154291
Code Inist : 002B02N. Création : 199608.