The prognostic significance of abnormal findings has not been demonstrated in a setting of mass screening.
To evaluate the relative risk of end-stage renal disease (ESRD) indicated by various results of community-based mass screening, we utilized the registries of both community mass screening and chronic dialysis programs.
In 1983, a total of 107,192 subjects over 18 years of age (51,122 men and 56,070 women) participated in dipstick urinalysis and blood pressure measurement in Okinawa, Japan.
During ten years of follow-up, we identified 193 dialysis patients (105 men and 88 women) among them.
Logistic regression analysis of clinical predictors of ESRD over 10 years was done and the adjusted odds ratio and 95% confidence interval calculated in each of the predictors with adjustment to others.
In the clinical predictors such as sex, age at screening, proteinuria, hematuria, systolic and diastolic blood pressure, proteinuria was the most potent predictor of ESRD (adjusted odds ratio 14.9,95% confidence interval 10.9 to 20.2), and the next most potent predictor was hematuria (adjusted odds ratio 2.30,95% confidence interval 1.62 to 3.28).
Being of male gender was a significant risk factor for ESRD (adjusted odds ratio 1.41,95% confidence interval 1.04 to 1.92).
Diastolic blood pressure was also a significant predictor of ESRD (adjusted odds ratio 1.39,95% confidence interval 1.17 to 1.64), but systolic blood pressure was not.
In a mass screening setting, pos...
Mots-clés Pascal : Insuffisance rénale, Chronique, Homme, Incidence, Analyse risque, Epidémiologie, Japon, Asie, Dépistage, Urine, Stade terminal, Appareil urinaire pathologie, Rein pathologie, Santé publique, Facteur prédictif
Mots-clés Pascal anglais : Renal failure, Chronic, Human, Incidence, Risk analysis, Epidemiology, Japan, Asia, Medical screening, Urine, Terminal stage, Urinary system disease, Renal disease, Predictive factor
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0153813
Code Inist : 002B14A05. Création : 199608.