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  1. Clara cell protein (CC-16) and surfactant-associated protein A (SP-A) in asbestos-exposed workers.

    Article - En anglais

    Asbestos-exposed workers (Asb) can sometimes develop lung impairments resembling idiopathic pulmonary fibrosis (IPF).

    Smoking is often a troubling confounder in the natural history of these lung diseases.

    Distal airspace epithelial cells, which are also altered in asbestosis, secrete Clara cell protein (CC-16, also designated CC-10) and surfactant-associated protein A (SP-A).

    By inhibiting phospholipase A#B2 (PLA#B2), CC-16 and SP-A are putative candidates for controlling lung inflammatory events.

    Both were measured with PLA#B2 activity in alveolar fluids (and sera for CC-16) of smoker and nonsmoker Asb and compared with smoking-matched normal subjects (N).

    CC-16 (in mg/L) was slightly increased in Asb and affected by smoking : nonsmoker Asb : 3.1rhô0.5 vs nonsmoker N : 1.9rhô0.2 (p<0.05), smoker Asb : 1.7rhô0.3 vs smoker N : 0.6rhô0.1 (p<0.05).

    SP-A (in ƒg/dL) was enhanced in Asb but not affected by smoking : 5.4rhô1.5 in Asb vs 1.6rhô0.4 in N (p<0.05), whereas SP-A to phosphorus ratio was increased in Asb but affected by smoking.

    CC-16 to albumin and CC-16 in serum to alveolar fluid ratios were altered by cigarette consumption in Asb (p<0.05 vs N).

    Secretory PLA#B2 activity was slightly enhanced in Asb (p<0.05 vs N).

    All data were similar between stages of disease.

    In summary, alveolar CC-16, SP-A, and secretory PLA#B2 activity were increased in Asb.

    Smoking affected several parameters.

    By this habit, Asb might reinforce lung profibrotic factors and incr...

    Mots-clés Pascal : Asbestose, Maladie professionnelle, Homme, Cellule Clara, Protéine, Marqueur biologique, Phospholipase A#B2, Inflammation, Fibrose, Poumon, Carboxylic ester hydrolases, Esterases, Hydrolases, Enzyme, Appareil respiratoire pathologie, Pneumoconiose, Poumon pathologie

    Mots-clés Pascal anglais : Asbestosis, Occupational disease, Human, Clara cell, Proteins, Biological marker, Phospholipase A#B2, Inflammation, Fibrosis, Lung, Carboxylic ester hydrolases, Esterases, Hydrolases, Enzyme, Respiratory disease, Pneumoconiosis, Lung disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0152435

    Code Inist : 002B30B01A. Création : 199608.