Asbestos-exposed workers (Asb) can sometimes develop lung impairments resembling idiopathic pulmonary fibrosis (IPF).
Smoking is often a troubling confounder in the natural history of these lung diseases.
Distal airspace epithelial cells, which are also altered in asbestosis, secrete Clara cell protein (CC-16, also designated CC-10) and surfactant-associated protein A (SP-A).
By inhibiting phospholipase A#B2 (PLA#B2), CC-16 and SP-A are putative candidates for controlling lung inflammatory events.
Both were measured with PLA#B2 activity in alveolar fluids (and sera for CC-16) of smoker and nonsmoker Asb and compared with smoking-matched normal subjects (N).
CC-16 (in mg/L) was slightly increased in Asb and affected by smoking : nonsmoker Asb : 3.1rhô0.5 vs nonsmoker N : 1.9rhô0.2 (p<0.05), smoker Asb : 1.7rhô0.3 vs smoker N : 0.6rhô0.1 (p<0.05).
SP-A (in g/dL) was enhanced in Asb but not affected by smoking : 5.4rhô1.5 in Asb vs 1.6rhô0.4 in N (p<0.05), whereas SP-A to phosphorus ratio was increased in Asb but affected by smoking.
CC-16 to albumin and CC-16 in serum to alveolar fluid ratios were altered by cigarette consumption in Asb (p<0.05 vs N).
Secretory PLA#B2 activity was slightly enhanced in Asb (p<0.05 vs N).
All data were similar between stages of disease.
In summary, alveolar CC-16, SP-A, and secretory PLA#B2 activity were increased in Asb.
Smoking affected several parameters.
By this habit, Asb might reinforce lung profibrotic factors and incr...
Mots-clés Pascal : Asbestose, Maladie professionnelle, Homme, Cellule Clara, Protéine, Marqueur biologique, Phospholipase A#B2, Inflammation, Fibrose, Poumon, Carboxylic ester hydrolases, Esterases, Hydrolases, Enzyme, Appareil respiratoire pathologie, Pneumoconiose, Poumon pathologie
Mots-clés Pascal anglais : Asbestosis, Occupational disease, Human, Clara cell, Proteins, Biological marker, Phospholipase A#B2, Inflammation, Fibrosis, Lung, Carboxylic ester hydrolases, Esterases, Hydrolases, Enzyme, Respiratory disease, Pneumoconiosis, Lung disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0152435
Code Inist : 002B30B01A. Création : 199608.