Neurotoxicity in operating room personnel working with gaseous and nongaseous anesthesia.
Occupational exposure to high concentrations of anesthetic gases (more than 500 ppm of nitrous oxide and more than 15 ppm of halothane and enflurane) can cause neurobehavioral effects in operating room personnel.
Factors such as stress and work organization play an additional role in reducing performance capacities.
It is still unclear whether these conditions may become the predominant factor in behavioral impairment when exposure to anesthetic gases is reduced ; in addition, we wished to ascertain the extent of neurobehavioral and neuroendocrine effects at relatively low levels of exposure to such gases.
Therefore the same group of 30 operating room personnel was examined with neurobehavioral tests during gaseous and nongaseous anesthesia.
In this way, the neuropsychological performance was examined under the same stress conditions, but with different exposure levels to anesthetic gases.
Serum cortisol was measured as an additional « biological stress indicator. » Prolactin secretion was examined to study possible interference of anesthetic gases with the dopaminergic system.
The results were compared with those in a control group of 20 hospital workers from other departments, with similar characteristics in respect of age, sex, and education.
During work with gaseous anesthesia, average airborne concentrations (geometric mean) of nitrous oxide were 50.9 ppm (SD 20.8) on the first day of the working week and 54.2 ppm (SD 22.1) on the last day of the workin...
Mots-clés Pascal : Azote protoxyde, Enflurane, Halothane, Anesthésique général, Exposition professionnelle, Bloc opératoire, Personnel sanitaire, Homme, Toxicité, Système nerveux pathologie, Comportement, Prolactine, Hydrocortisone, Stress, Gaz, Composé volatil, Voie dopaminergique, Relation dose réponse, Médecine travail
Mots-clés Pascal anglais : Nitrogen protoxide, General anesthetic, Occupational exposure, Operating room, Health staff, Human, Toxicity, Nervous system diseases, Behavior, Prolactin, Cortisol, Stress, Gases, Volatile compound, Dopaminergic pathway, Dose activity relation, Occupational medicine
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0151118
Code Inist : 002B02U01. Création : 199608.