Correct analysis of whole blood volatile organic compounds (VOCs) in evaluating possible exposure situations requires differentiation of smokers from nonsmokers.
Whole blood concentrations of 2,5-dimethylfuran are determined using an internal standard method, and the concentrations of this compound are evaluated as a marker for smoking in exposure-study subjects.
Results indicate that the concentration of 2,5-dimethylfuran can be adequately determined in whole blood by a method already in use for determining VOCs in blood.
The whole blood concentration of 2,5-dimethylfuran was an excellent predictor of smoking when compared with positive responses about smoking on questionnaires.
Using a detection limit of 0.024ppb, 2,5-dimethylfuran concentrations in blood correctly identified the smoking status of 96.4% of the subjects in this study.
The blood 2,5-dimethylfuran concentration was linearly related to the number of cigarettes smoked per day.
This method is advantageous since blood 2,5-dimethylfuran concentrations can be determined using the same method used to determine concentrations of other VOCs, thus obviating the need for additional analytical procedures.
Mots-clés Pascal : Tabagisme, Marqueur biologique, Sang, Analyse quantitative, Composé volatil, Composé organique, Fumeur, Homme, Santé publique, Furane(2,5-dimèthyl)
Mots-clés Pascal anglais : Tobacco smoking, Biological marker, Blood, Quantitative analysis, Volatile compound, Organic compounds, Smoker, Human
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0151117
Code Inist : 002B03E. Création : 199608.