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  1. Using the blood concentration of 2,5-dimethylfuran as a marker for smoking.

    Article - En anglais

    Correct analysis of whole blood volatile organic compounds (VOCs) in evaluating possible exposure situations requires differentiation of smokers from nonsmokers.

    Whole blood concentrations of 2,5-dimethylfuran are determined using an internal standard method, and the concentrations of this compound are evaluated as a marker for smoking in exposure-study subjects.

    Results indicate that the concentration of 2,5-dimethylfuran can be adequately determined in whole blood by a method already in use for determining VOCs in blood.

    The whole blood concentration of 2,5-dimethylfuran was an excellent predictor of smoking when compared with positive responses about smoking on questionnaires.

    Using a detection limit of 0.024ppb, 2,5-dimethylfuran concentrations in blood correctly identified the smoking status of 96.4% of the subjects in this study.

    The blood 2,5-dimethylfuran concentration was linearly related to the number of cigarettes smoked per day.

    This method is advantageous since blood 2,5-dimethylfuran concentrations can be determined using the same method used to determine concentrations of other VOCs, thus obviating the need for additional analytical procedures.

    Mots-clés Pascal : Tabagisme, Marqueur biologique, Sang, Analyse quantitative, Composé volatil, Composé organique, Fumeur, Homme, Santé publique, Furane(2,5-dimèthyl)

    Mots-clés Pascal anglais : Tobacco smoking, Biological marker, Blood, Quantitative analysis, Volatile compound, Organic compounds, Smoker, Human

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0151117

    Code Inist : 002B03E. Création : 199608.