The Tecumseh Community Health Study (TCHS), initiated in 1959 at the University of Michigan School of Public Health, has provided a resource for long term prospective studies of the incidence of cancer in the setting of a midwestern rural farming community.
A survey of total and site specific cancer incidence among 7016 male and female adult residents from 1959-1987 was conducted, and the observed number compared with the expected number, based on the age-sex-race-calendar period-and site-specific cancer incidence rates reported by the Connecticut tumor registry.
Based on the results of this survey, a hypothesis was advanced concerning the potential risks of exposures to insecticides and herbicides.
This was pursued by analyzing for each county in Michigan the comparative annual number of acres and percentage of acreage treated with agricultural chemicals in 1978 and for the period 1982-1987.
Finally, because of the availability of information on lifestyle risk factors that had been collected in the 1960s on all participants, a nested case-control study was implemented.
The standardized incidence ratio (SIR), based on the observed number divided by the expected number of invasive cancer cases (all sites combined epsilonexcluding nonmelanoma skin cancerzêta), was not significant in females (SIR, 0.95 ; 95% confidence interval epsilonCIzêta, 0.86-1.05) nor males (SIR, 0.91 ; 95% CI, 0.81-1.01).
A significant increase was demonst...
Mots-clés Pascal : Tumeur maligne, Hémopathie maligne, Adulte, Homme, Incidence, Epidémiologie, Zone rurale, Pesticide, Herbicide, Carcinogène, Agriculteur, Exposition professionnelle, Etude cohorte, Michigan, Etats Unis, Amérique du Nord, Amérique, Santé publique, Etude cas témoin
Mots-clés Pascal anglais : Malignant tumor, Malignant hemopathy, Adult, Human, Incidence, Epidemiology, Rural area, Pesticides, Herbicide, Carcinogen, Farmer, Occupational exposure, Cohort study, Michigan, United States, North America, America, Case control study
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0150530
Code Inist : 002B04B. Création : 199608.