We analyzed data from a population-based, multi-center, case-control study to determine whether the occurrence of histologic types of uterine sarcoma is related to exogenous hormone use and/or to two correlates of endogenous estrogens : excess weight and cigarette smoking.
One hundred sixty-seven women with newly-diagnosed uterine sarcoma (56 leiomyosarcoma, 85 mixed mu'llerian tumors, and 26 endometrial stromal sarcomas) were interviewed by telephone regarding possible risk factors for these neoplasms.
For comparison, 208 women identified at random from the general population of the study areas were interviewed as controls.
Use of oral contraceptives was positively associated with the risk of leiomyosarcoma (odds ratios epsilonORzêta=1.7,95% confidence interval epsilonCIzêta=0.7,4.1), primarily among women who last used these medications 15 or more years prior to diagnosis.
Use of noncontraceptive estrogens was directly associated with the risk of mixed mu'llerian tumors, but only among recent and long-term users of these medications.
Women in the highest quantile of body mass index (kappa 27.5 kg/m #F2) one year prior to diagnosis were at increased risk of each type of uterine sarcoma (leiomyosarcoma, OR=2.5,95% CI=1.1,5.7 ; mixed mu'llerian tumors, OR=2.9,95% CI=1.3,6.7 ; stromal sarcoma, OR=3.5,95% CI=1.1,10.9).
Women who had ever smoked cigarettes were at reduced risk of leiomyosarcoma (OR=0.6,95% CI=0.3,1.1) and stromal ...
Mots-clés Pascal : Sarcome, Utérus, Homme, Facteur risque, Epidémiologie, Type histologique, Oestrogène, Progestatif, Poids corporel, Tabagisme, Contraception, Endogène, Tumeur maligne, Appareil génital femelle pathologie, Utérus pathologie, Santé publique, Hormone stéroi`de sexuelle, Etude cas témoin
Mots-clés Pascal anglais : Sarcoma, Uterus, Human, Risk factor, Epidemiology, Histological type, Estrogen, Progestagen, Body weight, Tobacco smoking, Contraception, Endogenous, Malignant tumor, Female genital diseases, Uterine diseases, Sex steroid hormone, Case control study
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0150524
Code Inist : 002B20C02. Création : 199608.