In order to clarify the effects of acetone (AC) exposure on health, a cross-sectional study was carried out in 110 male AC-exposed and 67 male nonexposed shift workers.
The AC workers ranged in age from 18.7 to 56.8 years (mean : 37.6 years) and in length of AC exposure from 0.5 to 34.3 years (mean : 14.9 years).
The nonexposed workers ranged in age from 20.7 to 57.5 years (mean : 41.9 years).
AC exposure levels assessed by personal passive monitors and biological monitoring indices measured at the end of the workshift were 19.6-1018 ppm in the breathing zone (AC-E, mean : 364 ppm), 2.5-422 ppm in alveolar air (AC-A, mean : 97.3 ppm) 4-220 mg/l in blood (AC-B, mean 66.0 ppm), and 0.75-170 mg/l in urine (AC-U, mean : 37.8 mg/l).
Symptoms at the end of the workshift with good exposure-response relationships were eye irritation, tearing, and acetone odor, and symptoms within the previous 6 months with good exposure-response relationships were heavy, vague, or faint feeling in the head, nausea, loss of weight, and slow healing of an external wound.
In the 30-44 year age range, simple reaction time and digit span scores in a short computerized neurobehavioral test battery were significantly lower in AC workers, but exposure-response relationships were not clear.
Manifest Anxiety Scale scores, Self-rating Depression Scale scores, R-R interval variation on the ECG, hematological examinations, serum biochemistry examinations for liver function, and phagocytic acti...
Mots-clés Pascal : Acétone, Solvant organique, Exposition professionnelle, Toxicité, Homme, Fibre synthétique, Fibre artificielle, Industrie, Epidémiologie, Surveillance biologique, Médecine travail, Système nerveux pathologie
Mots-clés Pascal anglais : Acetone, Organic solvent, Occupational exposure, Toxicity, Human, Synthetic fiber, Artificial fiber, Industry, Epidemiology, Biological monitoring, Occupational medicine, Nervous system diseases
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0148433
Code Inist : 002B03L04. Création : 199608.