Leukaemia and non-Hodgkin's lymphoma in young persons resident in small areas of West Cumbria in relation to paternal preconceptional irradiation.
The results of a previous study suggested that an association between childhood leukaemia and the radiation dose received occupationally by a father before the conception of his child might provide the explanation for the marked excess of childhood leukaemia and non-Hodgkin's lymphoma in the village of Seascale, West Cumbria.
The present study identifies other small areas (electoral wards) in West Cumbria where excess cases of leukaemia and non-Hodgkin's lymphoma in young people have occurred and determines whether a recorded dose of radiation was received occupationally by the father before the conception of each of the affected individuals.
Forty-one cases of leukaemia and non-Hodgkin's lymphoma were diagnosed during 1968 85 in young people under 25 years of age resident in the 49 electoral wards lying within the boundary of West Cumbria and the adjacent ward of Broughton.
Raised incidence rate ratios (two-sided P<0.01) were found for acute lymphoblastic leukaemia among those aged 0-14 years (concentrated among those aged 0-4 years) in Seascale ward and among those aged 0-24 years (also concentrated among those aged 0-4 years) in Egremont North ward, for acute myeloid leukaemia among those aged 0-14 years in Sandwith ward, for all leukaemias among those aged 0-14 years in Broughton ward (South Lakeland) and for non-Hodgkin's lymphoma among those aged 0-14 years in Seascale ward.
For West Cumbria as a whole, incidence rates were not unusual.
Apart from Se...
Mots-clés Pascal : Lymphome non hodgkinien, Leucémie, Irradiation(personne), Exposition professionnelle, Père, Irradiation ionisante, Epidémiologie, Angleterre, Grande Bretagne, Royaume Uni, Europe, Enfant, Homme, Hémopathie maligne, Lymphoprolifératif syndrome, Médecine travail, Santé publique
Mots-clés Pascal anglais : Non Hodgkin lymphoma, Leukemia, Radiation exposure(person), Occupational exposure, Father, Ionizing irradiation, Epidemiology, England, Great Britain, United Kingdom, Europe, Child, Human, Malignant hemopathy, Lymphoproliferative syndrome, Occupational medicine
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0144920
Code Inist : 002B19B. Création : 199608.