United States military personnel deployed to Somalia were at risk for malaria, including chloroquine-resistant Plasmodium falciparum malaria.
This report details laboratory, clinical, preventive, and therapeutic aspects of malaria in this cohort.
The study took place in US military field hospitals in Somalia, with US troops deployed to Somalia between December 1992 and May 1993.
Centralized clinical care and country-wide disease surveillance facilitated standardized laboratory diagnosis, clinical records, epidemiologic studies, and assessment of chemoprophylactic efficacy.
Forty-eight cases of malaria occurred among US troops while in Somalia ; 41 of these cases were P falciparum.
Risk factors associated with malaria included :
noncompliance with recommended chemoprophylaxis (odds ratio epsilonORzêta 2.4) ;
failure to use bed nets (OR 2.6) ;
and failure to keep sleeves rolled down (OR 2.2).
Some patients developed malaria in spite of mefloquine (n=8) or doxycycline (n=5) levels compatible with chemoprophylactic compliance.
Five mefloquine failures had both serum levels kappa650 ng/mL and metabolite : mefloquine ratios over 2, indicating chemoprophylactic failure.
All cases were successfully treated, including 1 patient who developed cerebral malaria.
P falciparum malaria attack rates were substantial in the first several weeks of Operation Restore Hope.
While most cases occurred because of noncomplia...
Mots-clés Pascal : Plasmodium falciparum, Sporozoa, Protozoa, Paludisme, Protozoose, Parasitose, Infection, Militaire, Américain, Somalie, Afrique, Epidémiologie, Homme, Santé publique
Mots-clés Pascal anglais : Plasmodium falciparum, Sporozoa, Protozoa, Malaria, Protozoal disease, Parasitosis, Infection, Military, American, Somali Republic, Africa, Epidemiology, Human
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0142986
Code Inist : 002B05E02B4. Création : 199608.