Traduction en anglais : Prevention of osteoporosis : paradigm oestrogen substitution.
There is an increasing belief among most physicians that hormone replacement therapy (HRT) is unquestionable efficacious to prevent osteoporotic fractures in women after the menopause.
However, an analysis of the studies which are regarded as efficacy proof of HRT concerning the prevention of hip fractures - as the most important manifestation of osteoporosis - shows that the data are weaker than generally assumed : there are no randomised trials with regard to hip fracture prevention by HRT and the protective effect which is seen in the observational studies is inversely related to the methodical state of the respective type of study.
Consequently, a bias cannot be excluded, while the so-called'selection-by-health'-bias could play an outstanding role.
For the efficacy proof of a treatment randomised controlled trials cannot be replaced by results of observational studies, however impressive they may be.
Mots-clés Pascal : Ostéoporose, Prévention, Traitement substitutif, Oestrogène, Hormone stéroi`de sexuelle, Fracture, Hanche, Postménopause, Méthodologie, Essai clinique, Membre inférieur, Femme, Homme, Santé publique, Système ostéoarticulaire pathologie, Ostéopathie, Traumatisme
Mots-clés Pascal anglais : Osteoporosis, Prevention, Replacement therapy, Estrogen, Sex steroid hormone, Fracture, Hip, Postmenopause, Methodology, Clinical trial, Lower limb, Woman, Human, Diseases of the osteoarticular system, Bone disease, Trauma
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0141602
Code Inist : 002B15A. Création : 199608.