Time-integrated blood lead concentration is a valid surrogate for estimating the cumulative lead dose assessed by tibial lead measurement.
The concentration of lead in tibia (Pb-T) was measured in vivo by a #F1#F0#F9Cd K-shell X-ray fluorescence technique in 123 workers from a primary lead smelter (age : mean, 45 years ; range, 30-61 ; duration of employment : mean, 20 years ; range, 7-45).
Their cumulative blood lead index (CBLI) was also calculated on the basis of the blood lead (Pb-B) records available from the company's medical files.
Geometric mean for Pb-T was 49 g Pb/g bone mineral (range, 15-167).
The company's health surveillance programs, implemented since 1945, resulted in Pb-B values which rarely exceeded 70 g Pb/dl whole blood.
Pb-B at the time of Pb-T measurement averaged 31 g Pb/dl (range, 6-62) and the geometric mean for CBLI amounted to 803 g Pb/dl x year (range, 220-2130).
Despite various assumptions and uncertainties inherent in the assessment of the cumulative lead dose through Pb-T measurement or CBLI calculation, the relation between both variables in the present lead smelter population is very strong, (r#Bp#Be#Ba#Br#Bs#Bo#Bn=0.80, P<0.0001 ; age explained at the most 9.5% of the variance).
The slope of the regression equation of log Pb-T vs log CBLI showed that a doubling of CBLI also corresponds to a doubling of Pb-T.
It may be concluded that a sound calculation of CBLI represents a valid surrogate for estimating the life time integrated dose of lead as assessed by the measurement of cortical bone lead (e.g., in tibia).
Mots-clés Pascal : Plomb, Métal lourd, Toxicocinétique, Distribution, Accumulation, Méthode étude, Exposition professionnelle, Homme, Médecine travail, Taux, Analyse quantitative, Os, Matériel biologique, Sang, Dose cumulée, Fonderie, Industrie métallurgique, Liquide biologique, Surveillance biologique, Relation temps réponse
Mots-clés Pascal anglais : Lead, Heavy metal, Toxicokinetics, Distribution, Accumulation, Investigation method, Occupational exposure, Human, Occupational medicine, Rate, Quantitative analysis, Bone, Biological material, Blood, Cumulated dose, Foundry, Metallurgical industry, Biological fluid, Biological monitoring, Time response relation
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0141550
Code Inist : 002B03L05. Création : 199608.