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  1. Time-integrated blood lead concentration is a valid surrogate for estimating the cumulative lead dose assessed by tibial lead measurement.

    Article - En anglais

    The concentration of lead in tibia (Pb-T) was measured in vivo by a #F1#F0#F9Cd K-shell X-ray fluorescence technique in 123 workers from a primary lead smelter (age : mean, 45 years ; range, 30-61 ; duration of employment : mean, 20 years ; range, 7-45).

    Their cumulative blood lead index (CBLI) was also calculated on the basis of the blood lead (Pb-B) records available from the company's medical files.

    Geometric mean for Pb-T was 49 ƒg Pb/g bone mineral (range, 15-167).

    The company's health surveillance programs, implemented since 1945, resulted in Pb-B values which rarely exceeded 70 ƒg Pb/dl whole blood.

    Pb-B at the time of Pb-T measurement averaged 31 ƒg Pb/dl (range, 6-62) and the geometric mean for CBLI amounted to 803 ƒg Pb/dl x year (range, 220-2130).

    Despite various assumptions and uncertainties inherent in the assessment of the cumulative lead dose through Pb-T measurement or CBLI calculation, the relation between both variables in the present lead smelter population is very strong, (r#Bp#Be#Ba#Br#Bs#Bo#Bn=0.80, P<0.0001 ; age explained at the most 9.5% of the variance).

    The slope of the regression equation of log Pb-T vs log CBLI showed that a doubling of CBLI also corresponds to a doubling of Pb-T.

    It may be concluded that a sound calculation of CBLI represents a valid surrogate for estimating the life time integrated dose of lead as assessed by the measurement of cortical bone lead (e.g., in tibia).

    Mots-clés Pascal : Plomb, Métal lourd, Toxicocinétique, Distribution, Accumulation, Méthode étude, Exposition professionnelle, Homme, Médecine travail, Taux, Analyse quantitative, Os, Matériel biologique, Sang, Dose cumulée, Fonderie, Industrie métallurgique, Liquide biologique, Surveillance biologique, Relation temps réponse

    Mots-clés Pascal anglais : Lead, Heavy metal, Toxicokinetics, Distribution, Accumulation, Investigation method, Occupational exposure, Human, Occupational medicine, Rate, Quantitative analysis, Bone, Biological material, Blood, Cumulated dose, Foundry, Metallurgical industry, Biological fluid, Biological monitoring, Time response relation

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0141550

    Code Inist : 002B03L05. Création : 199608.