Serum prolactin in subjects occupationally exposed to manganese.
To evaluate whether or not occupational exposure to manganese (Mn) affects basal levels of serum prolactin (PRL), a cross-sectional study was carried out in 31 occupationally-exposed workers, aged 39.2 years (DS 7.9) exposed to manganese (Mn) dusts for 14.5 years (range : 5 to 29 years) in a ferroalloy producing plant.
Thirty-four industrial workers not exposed to neurotoxic chemicals and of comparable age composed the control group.
Airborne Mn concentrations in dusts of the furnace area ranged 210 to 980 mug/m3, which is below the current American Conference of Governmental Industrial Hygienists (ACGIH) - recommended threshold limit value-time weighted average (TLV-TWA) of 1 mg/m3.
Manganese concentrations in blood Mn (MnB) and in urine (MnU) were significantly higher in Mn-exposed workers as compared to control workers.
The Mn-exposed workers showed significantly higher serum prolactin (PRL) levels with the geometric mean (GM) being 9.77 ng/ml with a geometric standard deviation (GSD) of 1.69 as compared to controls (GM 4.65 ng/ml, GSD 1.78, p<0.001).
Serum PRL was negatively related to age and positively correlated with both MnB and MnU.
Dose-effect relationships were still significant in partial correlation analysis after control for age.
The prevalence of abnormally high PRL values was consistent with a dose-response relationship.
The observed increase in serum PRL among Mn-exposed workers suggests an impairment of tonic inhibition by tubero-infundib...
Mots-clés Pascal : Effet biologique, Exposition professionnelle, Manganèse, Taux concentration, Prolactine, Sérum, Exploration radioisotopique, Etude comparative, Homme, Médecine travail, Toxicologie
Mots-clés Pascal anglais : Biological effect, Occupational exposure, Manganese, Concentration factor, Prolactin, Serum, Radionuclide study, Comparative study, Human, Occupational medicine, Toxicology
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0129799
Code Inist : 002B03L05. Création : 199608.