The purpose of this cross-sectional study was to investigate whether the presence of serum respiratory virus antibodies was associated with reduced one-second forced expiratory volume (FEV1) in adults. of serum complement Methods.
From a stratified random sample of 18-73 year old adults, we performed measurements of serum complement fixing virus antibodies against influenza type A and B, parainfluenza type 1,2, and 3, respiratory syncytial virus and adenovirus on 82% (n=1239).
In the crude data, subjects having five of the seven virus antibodies had significantly lower lung function, given as sex-age-and height-standardized residuals of FEV1 (SFEV1), compared with those without.
After adjusting in addition for smoking habits, lifetime smoking consumption and season, the lung function levels were significantly lower in subjects with influenza type B and respiratory syncytial virus antibodies compared to those without (P<0.01).
Increasing influenza and respiratory syncytial virus antibody titres and increasing numbers of virus antibodies, respectively, were related to progressively lower lung function.
Subjects with respiratory symptoms but without obstructive lung disease had lower antibody levels than subjects with obstructive lung disease, but higher levels than asymptomatic subjects.
In a final multiple linear regression analysis adjusting in addition for respiratory symptom and disease status as well as for the other respiratory vir...
Mots-clés Pascal : Virose, Infection, Appareil respiratoire, Anticorps, Prédiction, Fonction respiratoire, Adulte, Homme, Epidémiologie, Norvège, Europe
Mots-clés Pascal anglais : Viral disease, Infection, Respiratory system, Antibody, Prediction, Lung function, Adult, Human, Epidemiology, Norway, Europe
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0123776
Code Inist : 002B05C02C. Création : 199608.